| Journal: | Revista médica del Hospital General de México |
| Database: | PERIÓDICA |
| System number: | 000439484 |
| ISSN: | 0185-1063 |
| Authors: | Flores Vargas, Abraham1 Campos García Rojas, Cuauhtémoc2 Jiménez Ponce, Fiacro3 |
| Institutions: | 1Hospital General de México, Departamento de Anestesiología, Ciudad de México. México 2Hospital General de México, Departamento de Cirugía Experimental, Ciudad de México. México 3Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México. México |
| Year: | 2019 |
| Season: | Ene-Mar |
| Volumen: | 82 |
| Number: | 1 |
| Pages: | 15-21 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Different rodent models of obsessive-compulsive disorder (OCD) have been used with the purpose for understanding this mental disease; in a previous article, we described quinpirole (QP) as a dopaminergic inductor of perseverative behavior. Objective: The objective of this study was to evaluate the decrease of QP-induced perseverative behavior observed in an open field after unilateral deep brain stimulation-low frequency (DBS-LF) into the orbitofrontal cortex (OFC) in Wistar rats. Materials and Methods: A total of 40 adult male Wistar rats were divided into three groups, each group underwent pharmacological treatment: sodium chloride (NaCl), QP, and clomipramine (CMP), these groups were not implanted with an electrode. An additional group was implanted into OFC Sham (SH), and after behavior evaluation, unilateral DBS-LF (6 Hz) was applied during night time for 5 min each side; first left side and after right side. Results: Distance traveled significantly decreased in the 5 min observed between QP and NaCl (p = 0.016), and a significant difference was found between NaCl and SH (p = 0.020). There was no significant difference between NaCl and CMP (p = 0.582) or NaCl and DBS-LF (p = 0.829). No significant difference between DBS left side and right side was found (p = 1.00). Conclusions: Unilateral DBS of the OFC prevents perseverative behavior in an open field, induced by QP |
| Disciplines: | Medicina |
| Keyword: | Neurología, Farmacología, Estimulación cerebral profunda, Corteza orbitofrontal, Quinpirola, Clomipramina, Modelos animales |
| Keyword: | Neurology, Pharmacology, Deep brain stimulation, Orbitofrontal cortex, Quinpirole, Clomipramine, Animal models |
| Full text: | https://www.hospitalgeneral.mx/frame_esp.php?id=16 |
