Comparing 8 mg versus 16 mg of dexamethasone as coadjuvant treatment for acute post-operative pain: A randomized controlled clinical trial
Document title: Comparing 8 mg versus 16 mg of dexamethasone as coadjuvant treatment for acute post-operative pain: A randomized controlled clinical trial
Journal: Revista médica del Hospital General de México
Database: PERIÓDICA
System number: 000439501
ISSN: 0185-1063
Authors: 1
1
1
2
Institutions: 1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Ciudad de México. México
2Hospital General de México, Departamento de Anestesiología, Ciudad de México. México
Year:
Season: Jul-Sep
Volumen: 82
Number: 3
Pages: 140-146
Country: México
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Glucocorticoids (IEA) have an analgesic effect by suppressing the release of inflammatory mediators that induce hyperalgesia, such as tumor necrosis factor-alpha, interleukin 8, and interleukin 6. Objectives: The objectives of this study were to compare two dosages of dexamethasone (DXM) (8 vs. 16 mg) as coadjuvant in the management of acute post-operative pain in patients undergoing ear, nose, and throat surgery. Materials and Methods: We included 80 patients in a double-blind clinical trial, divided into three groups that compared two different dosages of DXM with a control group that did not receive DXM, although all groups received intravenous (IV) analgesics. The post-operative pain report was assessed using a numeric rating scale, a post-operative pain visual analog scale (VAS), and recovery time 24-h after surgery. Descriptive statistics were used to apply the Chi-square test and ANOVA test for numerical variables. Results: Pain in Group 2 compared to Group 1 and Group 3 was less during recovery, after 1 h, and 24 h with p < 0.05 as with the post-operative pain VAS, p < 0.05. Opioid consumption was similar in the three groups. Conclusions: DXM 16 mg + Metamizole 1 g IV yields better analgesic effects compared to DXM 8 mg + metamizole 1 g in the immediate post-operative period and at 24 h
Disciplines: Medicina
Keyword: Cirugía,
Farmacología,
Dolor posoperatorio,
Adyuvantes,
Glucocorticoides,
Dexametasona
Keyword: Surgery,
Pharmacology,
Postoperative pain,
Adjuvants,
Glucocorticoids,
Dexamethasone
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