Revista: | Revista médica del Hospital General de México |
Base de datos: | PERIÓDICA |
Número de sistema: | 000439501 |
ISSN: | 0185-1063 |
Autores: | Rascón Martínez, Dulce María1 Olua Estrada, Jennifer1 Castellanos Olivares, Antonio1 Carrillo Torres, Orlando2 |
Instituciones: | 1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Ciudad de México. México 2Hospital General de México, Departamento de Anestesiología, Ciudad de México. México |
Año: | 2019 |
Periodo: | Jul-Sep |
Volumen: | 82 |
Número: | 3 |
Paginación: | 140-146 |
País: | México |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Glucocorticoids (IEA) have an analgesic effect by suppressing the release of inflammatory mediators that induce hyperalgesia, such as tumor necrosis factor-alpha, interleukin 8, and interleukin 6. Objectives: The objectives of this study were to compare two dosages of dexamethasone (DXM) (8 vs. 16 mg) as coadjuvant in the management of acute post-operative pain in patients undergoing ear, nose, and throat surgery. Materials and Methods: We included 80 patients in a double-blind clinical trial, divided into three groups that compared two different dosages of DXM with a control group that did not receive DXM, although all groups received intravenous (IV) analgesics. The post-operative pain report was assessed using a numeric rating scale, a post-operative pain visual analog scale (VAS), and recovery time 24-h after surgery. Descriptive statistics were used to apply the Chi-square test and ANOVA test for numerical variables. Results: Pain in Group 2 compared to Group 1 and Group 3 was less during recovery, after 1 h, and 24 h with p < 0.05 as with the post-operative pain VAS, p < 0.05. Opioid consumption was similar in the three groups. Conclusions: DXM 16 mg + Metamizole 1 g IV yields better analgesic effects compared to DXM 8 mg + metamizole 1 g in the immediate post-operative period and at 24 h |
Disciplinas: | Medicina |
Palabras clave: | Cirugía, Farmacología, Dolor posoperatorio, Adyuvantes, Glucocorticoides, Dexametasona |
Keyword: | Surgery, Pharmacology, Postoperative pain, Adjuvants, Glucocorticoids, Dexamethasone |
Texto completo: | https://www.hospitalgeneral.mx/frame_esp.php?id=33 |