| Journal: | Revista médica de Chile |
| Database: | PERIÓDICA |
| System number: | 000455006 |
| ISSN: | 0034-9887 |
| Authors: | Briones, Eduardo1 Méndez, Gonzalo P1 Laguna, Jorge1 Vargas, Miguel2 |
| Institutions: | 1Clínica Indisa, Santiago de Chile. Chile 2Merkén Biotech, Santiago de Chile. Chile |
| Year: | 2022 |
| Season: | Jun |
| Volumen: | 150 |
| Number: | 6 |
| Pages: | 828-831 |
| Country: | Chile |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | Renal involvement in COVID-19 infection is varied and worsens its outcome and prognosis. However, the association of COVID-19 infection with glomerulonephritis is exceptional. We report a 46-year-old woman with COVID-19 who had an acute kidney injury and ANCA associated glomerulonephritis two weeks after the onset of the disease. The kidney biopsy showed a crescentic glomerulo-nephritis and the presence of anti-glomerular basement membrane antibodies (GBM-Abs). She was treated with steroids and oral cyclophosphamide with good response without requiring plasmapheresis. Plasma anti GBM-Abs were negative. This case suggests that the presence of anti-GBM-Abs in the kidney, was temporally related to COVID-19 pulmonary damage. The absence of plasma antibodies is probably due to transient production and glomerular adsorption, but with unknown pathogenic role |
| Disciplines: | Medicina |
| Keyword: | Nefrología, Inmunología, Anticuerpos citoplásmicos antineutrófilos, Enfermedad anti-glomerular de la membrana basal, COVID-19, Glomerulonefritis, Plasmaféresis |
| Keyword: | Nephrology, Immunology, Antineutrophil cytoplasmic antibodies, Anti-glomerular basement membrane disease, COVID-19, Glomerulonephritis, Plasmapheresis |
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