Study on the possible protective effect of melatonin and silymarin against the toxic effect of favism factor "Divicine"
Document title: Study on the possible protective effect of melatonin and silymarin against the toxic effect of favism factor "Divicine"
Journal: Revista latinoamericana de química
Database: PERIÓDICA
System number: 000343700
ISSN: 0370-5943
Authors: 1
1
1
Institutions: 1National Research Centre, Medical Research Division, Dokki, Cairo. Egipto
Year:
Volumen: 38
Number: 1
Pages: 12-20
Country: México
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
Spanish abstract El objetivo del presente estudio fue elucidar el posible efecto protector de a melatonina y la Silimarina en caso de efectos tóxicos de DV en ratas albinas. En la administración IP de DV se tuvo el 100% de mortalidad y una disminución de la concentración de GSH en RBCs. La administración de Mt y Sy con DV reducen la mortalidad y el aumento de la concentración de GSH. Asimismo se observa que contrarresta el aumento de los parámetros en el hígado y en las funciones renales después de la inyección de DV
English abstract Experiments were carried–out with Sprague Dawley rats to determine as the administration of Mt and Sy on the toxicity produced by DV, a free radical compound. IP injection of DV (250 mg/rat b.wt.) alone resulted in 100% mortality within 24 h accompanied by a rapid decrease in the concentration of GSH in RBCs. Administration of both doses of Mt (1 and 2 mg/kg) and Sy (22 mg/kg) with DV greatly reduced mortality and increased the concentration of GSH. Blood cells and hemoglobin also returned towards normal values. Liver enzymes (AST, ALT, ALP and bilirubin) and kidney function (urea and creatinine) were highly significant increased after divicine injection, while Mt and Sy in combination with DV returned these parameters to normal values
Disciplines: Química,
Medicina
Keyword: Farmacología,
Toxicología,
Angiospermas,
Bioensayos,
Efecto protector,
Melatonina,
Silimarina,
Favismo,
Anemia hemolítica,
Vicia faba
Keyword: Chemistry,
Medicine,
Pharmacology,
Toxicology,
Angiosperms,
Bioassays,
Protective effect,
Melatonin,
Silymarin,
Favism,
Hemolytic anemia,
Vicia faba
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