| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000547838 |
| ISSN: | 0036-4665 |
| Authors: | Martins, Luciamáre Perinetti Alves1 Fukasawa, Josianne Thomazini2 Messias, Mirella Beni Balbino Ferreira2 Castanho, Roberto Esteves Pires1 Andrade, Leticia Abrantes3 Sperança, Márcia Aparecida3 Suzuki, Rodrigo Buzinaro2 |
| Institutions: | 1Disciplina de Parasitologia, Faculdade de Medicina de Marília, São Paulo. Brasil 2Hospital das Clínicas, Faculdade de Medicina de Marília, São Paulo. Brasil 3Universidade Federal do ABC, Centro de Ciências Naturais e Humanas, São Paulo, São Paulo. Brasil 4Universidade de Marília, Faculdade de Medicina, São Paulo, São Paulo. Brasil |
| Year: | 2022 |
| Volumen: | 64 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | Visceral leishmaniasis (VL) is an opportunistic disease in immunosuppressed individuals, who may present severe clinical conditions, such as the ones described in this patient. She lived in an endemic region for VL, and was possibly infected with L. (L.) infantum chagasi through the bite of a contaminated sand fly. This initial infection has triggered a pemphigus vulgaris condition by immunogenic proteins present in the mosquito's saliva. The immunosuppression caused by the use of high doses of corticosteroids to control the disease promoted a severe VL condition, with hepatosplenomegaly, thrombocytopenia and hemorrhages, requiring hospitalization and the onset of a subsequent SARS-CoV-2 infection. Due to the intensity of clinical manifestations related to VL, aggravated by COVID-19, she died two days after admission to the Clinical Hospital of Marilia Medical School (HC–Famema). |
| Keyword: | Visceral leishmaniasis, COVID-19, Immunosuppression, Pemphigus vulgaris |
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