SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil
Document title: SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil
Journal: Revista do Instituto de Medicina Tropical de Sao Paulo
Database:
System number: 000547822
ISSN: 0036-4665
Authors: 1
2
3
4
5
4
1
4
4
Institutions: 1Secretaria Municipal de Saúde, Santo André, São Paulo. Brasil
2Universidade do Estado de São Paulo, Botucatu, São Paulo. Brasil
3Instituto Adolfo Lutz, Centro de Laboratório Regional Santo André, Santo André, São Paulo. Brasil
4Instituto Adolfo Lutz, Centro de Virologia, São Paulo, São Paulo. Brasil
5Instituto Adolfo Lutz, Centro de Imunologia, São Paulo, São Paulo. Brasil
Year:
Volumen: 64
Country: Brasil
Language: Inglés
English abstract The COVID-19 pandemic in Brazil has been marked by high infection and death rates. The immune response generated by current vaccination might be influenced by previous natural infection, and baseline estimates may help in the evaluation of vaccine-induced serological response. We evaluated previous SARS-CoV-2 testing (RT-PCR), and performed rapid diagnostic tests (RDT) and high throughput electrochemiluminescence immunoassay (ECLIA) before vaccination among people living with HIV (PLWH), users of antiretroviral prophylaxis (PrEP/PEP), and healthcare professionals in an HIV outpatient clinic (HCP-HC). RDT was positive in 25.7% (95% CI: 19-33%) overall, 31.3% (95% CI : 18-45%) among PLWH, 23.7% (95% CI : 14-34%) in PrEP/PEP users and 21.4% (95% CI : 05-28%) in HCP-HC (p=0.548). Diagnostic RT-PCR testing was very limited, even for symptomatic individuals, and whereas all HCP-HC had one test perfomed, only 35% of the patients (PREP/PEP/PLWH) were tested (p<0.0001). Adequate monitoring of post-vaccination humoral response and breakthrough infections including those in asymptomatic cases are warranted, especially in immunologically compromised individuals.
Keyword: SARS-CoV-2,
HIV,
PrEP,
PEP,
Health care personals,
Prevalence
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