Revista: | Revista do Instituto de Medicina Tropical de Sao Paulo |
Base de datos: | |
Número de sistema: | 000547822 |
ISSN: | 0036-4665 |
Autors: | Matsuda, Elaine Monteiro1 Oliveira, Isabela Penteriche de2 Campos, Ivana Barros de3 Ahagon, Cintia Mayumi4 Castejon, Marcia Jorge5 Silva, Valeria Oliveira4 Manzoni, Fernanda Matsuda1 López Lopes, Giselle Ibette4 Brígido, Luís Fernando de Macedo4 |
Institucions: | 1Secretaria Municipal de Saúde, Santo André, São Paulo. Brasil 2Universidade do Estado de São Paulo, Botucatu, São Paulo. Brasil 3Instituto Adolfo Lutz, Centro de Laboratório Regional Santo André, Santo André, São Paulo. Brasil 4Instituto Adolfo Lutz, Centro de Virologia, São Paulo, São Paulo. Brasil 5Instituto Adolfo Lutz, Centro de Imunologia, São Paulo, São Paulo. Brasil |
Any: | 2022 |
Volum: | 64 |
País: | Brasil |
Idioma: | Inglés |
Resumen en inglés | The COVID-19 pandemic in Brazil has been marked by high infection and death rates. The immune response generated by current vaccination might be influenced by previous natural infection, and baseline estimates may help in the evaluation of vaccine-induced serological response. We evaluated previous SARS-CoV-2 testing (RT-PCR), and performed rapid diagnostic tests (RDT) and high throughput electrochemiluminescence immunoassay (ECLIA) before vaccination among people living with HIV (PLWH), users of antiretroviral prophylaxis (PrEP/PEP), and healthcare professionals in an HIV outpatient clinic (HCP-HC). RDT was positive in 25.7% (95% CI: 19-33%) overall, 31.3% (95% CI : 18-45%) among PLWH, 23.7% (95% CI : 14-34%) in PrEP/PEP users and 21.4% (95% CI : 05-28%) in HCP-HC (p=0.548). Diagnostic RT-PCR testing was very limited, even for symptomatic individuals, and whereas all HCP-HC had one test perfomed, only 35% of the patients (PREP/PEP/PLWH) were tested (p<0.0001). Adequate monitoring of post-vaccination humoral response and breakthrough infections including those in asymptomatic cases are warranted, especially in immunologically compromised individuals. |
Keyword: | SARS-CoV-2, HIV, PrEP, PEP, Health care personals, Prevalence |
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