| Journal: | Revista do Colegio Brasileiro de Cirurgioes |
| Database: | PERIÓDICA |
| System number: | 000283527 |
| ISSN: | 0100-6991 |
| Authors: | Goncalves, Carolina Gomes1 Coelho, Julio Cezar Uili Amarante, Heda Maria Barska dos Santos |
| Institutions: | 1Hospital Nossa Senhora das Gracas, Servico de Cirurgia Geral, Curitiba, Parana. Brasil |
| Year: | 2005 |
| Season: | Jul-Ago |
| Volumen: | 32 |
| Number: | 4 |
| Pages: | 223-224 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | Crohn's disease is often complicated by the development of fistulas. Infliximab, a monoclonal antibody that binds tumor necrosis factor a have shown to be successful in the treatment of fistulizing Crohn's disease. It's possible complications and side effects have not been completely elucidated. Our objective is to report a case of a patient who developed intestinal obstruction after treatment of fistulizing Crohn's disease with infliximab. A 50 years-old female with Crohn's disease presented with spontaneous enterocutaneous fistula. She was successfully treated with the infusion of 5mg/kg infliximab at weeks 0, 2, and 6, with complete closure of the fistula after the first infusion. Eight weeks after treatment she developed small bowel obstruction secondary to stenosis of the ileum. She was subjected to exploratory laparotomy and resection of the stenotic ileum. The patient had good recovery, with no complications, and was discharged on the 5th postoperative day. Although a faster and complete healing of enterocutaneous fistula was induced by infliximab, this treatment may have caused intestinal obstruction in this case |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Gastroenterología, Terapéutica y rehabilitación, Enfermedad de Crohn, Fístulas, Obstrucción intestinal, Inducción, Medicamentos |
| Keyword: | Medicine, Gastroenterology, Surgery, Therapeutics and rehabilitation, Crohn disease, Fistulae, Intestinal obstruction, Induction, Drugs |
| Full text: | Texto completo (Ver HTML) |
