| Revista: | Revista do Colegio Brasileiro de Cirurgioes |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000283527 |
| ISSN: | 0100-6991 |
| Autors: | Goncalves, Carolina Gomes1 Coelho, Julio Cezar Uili Amarante, Heda Maria Barska dos Santos |
| Institucions: | 1Hospital Nossa Senhora das Gracas, Servico de Cirurgia Geral, Curitiba, Parana. Brasil |
| Any: | 2005 |
| Període: | Jul-Ago |
| Volum: | 32 |
| Número: | 4 |
| Paginació: | 223-224 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Crohn's disease is often complicated by the development of fistulas. Infliximab, a monoclonal antibody that binds tumor necrosis factor a have shown to be successful in the treatment of fistulizing Crohn's disease. It's possible complications and side effects have not been completely elucidated. Our objective is to report a case of a patient who developed intestinal obstruction after treatment of fistulizing Crohn's disease with infliximab. A 50 years-old female with Crohn's disease presented with spontaneous enterocutaneous fistula. She was successfully treated with the infusion of 5mg/kg infliximab at weeks 0, 2, and 6, with complete closure of the fistula after the first infusion. Eight weeks after treatment she developed small bowel obstruction secondary to stenosis of the ileum. She was subjected to exploratory laparotomy and resection of the stenotic ileum. The patient had good recovery, with no complications, and was discharged on the 5th postoperative day. Although a faster and complete healing of enterocutaneous fistula was induced by infliximab, this treatment may have caused intestinal obstruction in this case |
| Disciplines | Medicina |
| Paraules clau: | Cirugía, Gastroenterología, Terapéutica y rehabilitación, Enfermedad de Crohn, Fístulas, Obstrucción intestinal, Inducción, Medicamentos |
| Keyword: | Medicine, Gastroenterology, Surgery, Therapeutics and rehabilitation, Crohn disease, Fistulae, Intestinal obstruction, Induction, Drugs |
| Text complet: | Texto completo (Ver HTML) |
