| Revista: | Revista de saude publica |
| Base de datos: | |
| Número de sistema: | 000535666 |
| ISSN: | 0034-8910 |
| Autores: | Costa, Nicole Rezende da1 Mancine, Livia2 Salvini, Rogerio2 Teixeira, Juliana de Melo2 Rodriguez, Roberta Diehl1 Leite, Renata Elaine Paraizo1 Nascimento, Camila1 Pasqualucci, Carlos Augusto1 Nitrini, Ricardo1 Jacob Filho, Wilson1 Lafer, Beny1 Grinberg, Lea Tenenholz1 Suemoto, Claudia Kimie1 Nunes, Paula Villela1 |
| Instituciones: | 1Universidade de São Paulo, Faculdade de Medicina, São Paulo. Brasil 2Universidade Federal de Goiás, Instituto de Informática, Goiânia, Goiás. Brasil |
| Año: | 2022 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Resumen en inglés | OBJECTIVE To establish a microcephaly cut-off size in adults using head circumference as an indirect measure of brain size, as well as to explore factors associated with microcephaly via data mining. METHODS In autopsy studies, head circumference was measured with an inelastic tape placed around the skull. Total brain volume was also directly measured. A linear regression was used to determine the association of head circumference with brain volume and clinical variables. Microcephaly was defined as head circumference that were two standard deviations below the mean of significant clinical variables. We further applied an association rule mining to find rules associating microcephaly with several sociodemographic and clinical variables. RESULTS In our sample of 2,508 adults, the mean head circumference was 55.3 ± 2.7cm. Head circumference was related to height, cerebral volume, and sex (p < 0.001 for all). Microcephaly was present in 4.7% of the sample (n = 119). Out of 34,355 association rules, we found significant relationships between microcephaly and a clinical dementia rating (CDR) > 0.5 with an informant questionnaire on cognitive decline in the elderly (IQCODE) ≥ 3.4 (confidence: 100% and lift: 5.6), between microcephaly and a CDR > 0.5 with age over 70 years (confidence: 42% and lift: 2.4), and microcephaly and males (confidence: 68.1% and lift: 1.3). CONCLUSION Head circumference was related to cerebral volume. Due to its low cost and easy use, head circumference can be used as a screening test for microcephaly, adjusting it for gender and height. Microcephaly was associated with dementia at old age. |
| Disciplinas: | Medicina |
| Palabras clave: | Anatomía humana |
| Keyword: | Human anatomy |
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