| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000456936 |
| ISSN: | 0034-8376 |
| Autores: | Hernández Oropeza, José Luis1 Rodríguez Reyna, Tatiana Sofía2 Carrillo Pérez, Diego Luis3 Rodríguez Andoney, José de Jesús1 Narváez David, René4 Salado Morales, Yesenia1 Rivero Sigarroa, Eduardo5 Domínguez Cherit, Guillermo5 Pulido Zamudio, Tomás6 |
| Instituciones: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Enfermedades Cardiopulmonares, Ciudad de México. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Inmunología y Reumatología, Ciudad de México. México 3Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Medicina Interna, Ciudad de México. México 4Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Cardiología, Ciudad de México. México 5Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Medicina y Cuidados Críticos, Ciudad de México. México 6Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Enfermedades Cardiopulmonares, Ciudad de México. México |
| Año: | 2018 |
| Volumen: | 70 |
| Número: | 2 |
| Paginación: | 82-87 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Pulmonary arterial hypertension (PAH) is a fatal complication in patients with connective tissue disease (CTD). Objective: The objective of the study was to study the prognostic value of the acute pulmonary vasoreactivity test with inhaled iloprost and its association with clinical deterioration in a tertiary care academic medical center. Methods: We conducted a prospective study of patients with CTD and the diagnosis of PAH established by right heart catheterization. Patients were classified into classic responders, partial responders, and non-responders. The association of the pulmonary response and clinical deterioration was analyzed. Results: We enrolled 25 patients (mean age of 47 ± 13.4 years); 88% were female The most frequent rheumatologic diagnosis was systemic lupus erythematosus, in 16 (64%) patients. Seventy-two percent of patients were classified as non-responders, and 28% were partial responders. Patients with a partial response had lower right atrial pressure values (5.1 ± 3.1 vs. 8.5 ± 3.2, p = 0.01) and greater systolic pulmonary arterial pressure (87.6 ± 8.1 vs. 72.4 ± 16.2, p = 0.02), compared with non-responders. Non-responders had a tendency for a shorter time to clinical deterioration than partial responders (17.8 vs. 41.1 months, p = 0.052). Conclusions: Patients with a partial response to the acute pulmonary vasodilator test with inhaled iloprost had a longer clinical deterioration-free period than non-responders. ( |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Neumología, Enfermedades del tejido conjuntivo, Vasorreactividad pulmonar, Hipertensión arterial pulmonar, Cateterismo |
| Keyword: | Cardiovascular system, Pneumology, Connective tissue diseases, Pulmonary vasoreactivity, Pulmonary arterial hypertension, Catheterization |
| Texto completo: | https://www.medigraphic.com/pdfs/revinvcli/nn-2018/nn182d.pdf |
