Polymorphisms in B-Adrenergic Receptors Are Associated with Increased Risk to Have a Positive Head-Up Tilt Table Test in Patients with Vasovagal Syncope
Título del documento: Polymorphisms in B-Adrenergic Receptors Are Associated with Increased Risk to Have a Positive Head-Up Tilt Table Test in Patients with Vasovagal Syncope
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000454199
ISSN: 0034-8376
Autores: 1
2
1
1
4
1
2
Instituciones: 1Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Electrofisiología, Ciudad de México. México
2Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Biología Molecular, Ciudad de México. México
3Universidad Nacional Autónoma de México, Facultad de Medicina, Ciudad de México. México
4Instituto Politécnico Nacional, Centro de Investigación y de Estudios Avanzados, Ciudad de México. México
Año:
Periodo: Mar-Abr
Volumen: 71
Número: 2
Paginación: 124-132
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Background Vasovagal syncope (VVS) is a frequent clinical condition in which a genetic background seems to be implicated. Considering that the adrenergic receptors (ARs) may play a role in VVS, the present study has as principal aim to determine if the α- and β-AR (ADRA and ADRB) gene polymorphisms are associated with an increased risk to have a positive head-up tilt table (HUTT) test in patients with VVS. Methods: Nine polymorphisms in the ADRA1A (rs1048101, rs1383914, rs574584, and rs573542), ADRB1 (rs1801252 and rs1801253), ADRB2 (rs1042713 and rs1042714), and ADRB3 (rs4994) genes were analyzed using the 5’ exonuclease TaqMan genotyping assay in a group of 134 patients with VVS. Results Under different models, the rs1801252 (OR = 8.63, 95% CI: 0.95-78.72, Precessive = 0.02), rs1042713 (OR = 1.94, 95% CI: 1.02-3.66, Padditive = 0.04), and rs4994 (OR = 2.46, 95% CI: 1.01-6.01, Pdominant = 0.042 and OR = 2.62, 95% CI: 1.04-6.63, Pover-dominant = 0.03) polymorphisms were associated with increased risk for a positive HUTT. All models were adjusted for statistically significant covariates. Conclusion These results suggest that some polymorphisms of the β-AR genes could contribute to a positive tilt test in patients with VVS
Disciplinas: Medicina
Palabras clave: Genética,
Sistema cardiovascular,
Receptores adrenérgicos,
Prueba de inclinación,
Polimorfismo genético,
Síncope vasovagal
Keyword: Genetics,
Cardiovascular system,
Adrenergic receptors,
Head-up tilt test,
Genetic polymorphism,
Vasovagal syncope
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