| Journal: | Revista de investigación clínica |
| Database: | PERIÓDICA |
| System number: | 000452961 |
| ISSN: | 0034-8376 |
| Authors: | Clavijo Cornejo, Denise1 López Reyes, Alberto2 Cruz Arenas, Esteban3 Jacobo Albavera, Leonor4 Rivera Tlaltzicapa, Daniel5 Francisco Balderas, Adriana6 Domínguez Pérez, Mayra7 Romero Morelos, Pablo8 Vázquez Mellado, Janitzia9 Silveira, Luis H10 Pineda, Carlos1 Martínez Nava, Gabriela10 Gutierrez, Marwin1 |
| Institutions: | 1Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, División de Enfermedades Musculoesqueléticasa y Reumáticas, Ciudad de México. México 2Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Laboratorio de Gerociencias, Ciudad de México. México 3Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Unidad de Vigilancia Epidemiológica Hospitalaria, Ciudad de México. México 4Instituto Nacional de Medicina Genómica, Laboratorio de Genómica Cardiovascular, Ciudad de México. México 5Universidad Autónoma Metropolitana, Ciudad de México. México 6Instituto Politécnico Nacional, Escuela Superior de Medicina, Ciudad de México. México 7Universidad Estatal del Valle de Ecatepec, Ecatepec, Estado de México. México 8Hospital General de México, Departamento de Reumatología, Ciudad de México. México 9Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Reumatología, Ciudad de México. México 10Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Laboratorio de Fluído Sinovial, Ciudad de México. México |
| Year: | 2022 |
| Season: | May-Jun |
| Volumen: | 74 |
| Number: | 3 |
| Pages: | 147-155 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility. Methods: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs. Results: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs. Conclusion: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility |
| Disciplines: | Medicina |
| Keyword: | Reumatología, Genética, Gota, Inflamasoma, Polimorfismo genético |
| Keyword: | Rheumatology, Genetics, Gout, Inflammasome, Genetic polymorphism |
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