| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000456905 |
| ISSN: | 0034-8376 |
| Autores: | Rodríguez, Alejandra1 Pajukanta, Päivi1 |
| Instituciones: | 1University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, California. Estados Unidos de América |
| Año: | 2018 |
| Volumen: | 70 |
| Número: | 5 |
| Paginación: | 217-223 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Cardiovascular disease (CVD) is a broad definition for diseases of the heart and blood vessels with high mortality and morbidity worldwide. Atherosclerosis and hypertension are the most common causes of CVD, and multiple factors confer the susceptibility. Some of the predisposing factors are modifiable such as diet, smoking, and exercise, whereas others, including age, sex, and individual’s genetic variations contributing to the CVD composition traits, are non-modifiable. This latter group includes serum lipid traits. High serum lipid levels, specifically high levels of serum low-density lipoprotein cholesterol and triglycerides, are well-established key risk factors of atherosclerosis. This review will discuss genomics and systems biology approaches in the study of common dyslipidemias. The non-Mendelian forms of dyslipidemias are highly complex, and the molecular mechanisms underlying these polygenic lipid disorders are estimated to involve hundreds of genes. Interactions between the different genes and environmental factors also contribute to the clinical outcomes; however, very little is known about these interactions and their molecular mechanisms. To better address the complex genetic architecture and multiple properties leading to high serum lipid levels, networks and systems approach combining information at genomic, transcriptomics, methylomics, proteomics, metabolomics, and phenome level are being developed, with the ultimate goal to elucidate the cascade of dynamic changes leading to CVD in humans |
| Disciplinas: | Medicina |
| Palabras clave: | Metabolismo y nutrición, Genética, Sistema cardiovascular, Enfermedades cardiovasculares, Etiología, Trastornos lipídicos, Metabolómica, Epigenética, Transcriptómica, Biología de sistemas |
| Keyword: | Metabolism and nutrition, Genetics, Cardiovascular system, Cardiovascular diseases, Etiology, Lipid disorders, Metabolomics, Epigenetics, Transcriptomics, Systems biology |
| Texto completo: | https://www.medigraphic.com/pdfs/revinvcli/nn-2018/nn185c.pdf |
