| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454198 |
| ISSN: | 0034-8376 |
| Autores: | Torre Saldaña, Viridiana A. de la1 Gómez Sámano, Miguel Ángel1 Gómez Pérez, Francisco Javier1 Rosas Saucedo, Juan1 León Suárez, Andrés1 Grajales Gómez, Mariana1 Oseguera Moguel, Jorge2 Vega Beyhart, Arturo1 Cuevas Ramos, Daniel1 |
| Instituciones: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Endocrinología y Metabolismo, Ciudad de México. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Cardiología, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | Mar-Abr |
| Volumen: | 71 |
| Número: | 2 |
| Paginación: | 133-140 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Irisin is a protein cleaved from fibronectin type III domain-containing protein 5 and has been implicated in the beneficial effects of exercise. However, it is unknown which factors contribute to irisin increment after intensive exercising in humans. This study aimed to assess independent factors related with serum irisin after 2 weeks of supervised physical activity in young sedentary healthy women. Design and Methods We developed a comparative, interventional, longitudinal, and prospective study at a third-level specialty health center. Between March 2010 and August 2011, 82 sedentary young adult women, without chronic diseases or regular medical treatments, were recruited. A total of 38 women fulfilled selection criteria, and irisin concentrations were quantified before and after the intervention. Independent factors related with irisin increment were evaluated according to mild to moderate and vigorous intensity of physical activity. A supervised treadmill exercise test following the Bruces protocol was conducted from Monday to Friday during 2 weeks. In addition, anthropometric measurements were taken, and fibroblast growth factor 21 (FGF21), glucose, insulin, and liver transaminases were measured. Results Intensity of exercising was directly related to irisin (p = 0.02) and FGF21 (p = 0.01) serum levels. However, an independent and significant relationship between FGF21 and irisin was not confirmed. A novel association was found between alanine aminotransferase (ALT) and irisin, showing a positive and significant correlation (r = 0.37, p = 0.02). The association was particularly strong with higher intensity of aerobic exercising (r = 0.64, p = 0.01). Linear regression model adjusted for glucose and body mass index confirmed an independent association between ALT and irisin and also between insulin and irisin (adjusted R² = 0.12, p = 0.04). Such association increased after grouping in moderate to vigorous physical activity intensity (a |
| Disciplinas: | Medicina |
| Palabras clave: | Metabolismo y nutrición, Ejercicio físico, Factor de crecimiento de fibroblastos, Irisina, Insulina, Alanina aminotransferasa |
| Keyword: | Metabolism and nutrition, Physical exercise, Fibroblast growth factor, Irisin, Insulin, Alanine aminotransferase |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
