| Journal: | Revista de investigación clínica |
| Database: | PERIÓDICA |
| System number: | 000453038 |
| ISSN: | 0034-8376 |
| Authors: | Díaz, Lorenza1 Zambrano, Elena1 Flores, María E1 Contreras, Mariela1 Crispín, Jose C1 Alemán, Gabriela1 Bravo, César1 Armenta, Alejandra1 Valdés, Victor J1 Tovar, Armando1 Gamba, Gerardo1 Barrios Payán, Jorge1 Bobadilla, Norma A1 |
| Institutions: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Comité Institutcional de Uso y Cuidado Animal, Ciudad de México. México |
| Year: | 2021 |
| Season: | Jul-Ago |
| Volumen: | 73 |
| Number: | 4 |
| Pages: | 199-209 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | In the last century, progress in the knowledge of human diseases, their diagnosis and treatment have grown exponentially, due in large part to the introduction and use of laboratory animals. Along with this important progress, the need to provide training and guidance to the scientific community in all aspects related to the proper use of experimental animals has been indispensable. Animal research committees play a primary role in evaluating experimental research protocols, from their feasibility to the rational use of animals, but above all in seeking animal welfare. The Institutional Committee for the Care and Use of Animals (IACUC) has endeavored to share several relevant aspects in conducting research with laboratory animals. Here, we present and discuss the topics that we consider of utmost importance to take in the account during the design of any experimental research protocol, so we invite researchers, technicians, and undergraduate and graduate students to dive into the fascinating subject of proper animal care and use for experimentation. The main intention of these contributions is to sensitize users of laboratory animals for the proper and rational use of them in experimental research, as well as to disseminate the permitted and unpermitted procedures in laboratory animals. In the first part, the significance of experimental research, the main functions of IACUC, and the principle of the three R’s (replacement, reduction, and refinement) are addressed |
| Disciplines: | Medicina |
| Keyword: | Investigación médica, Bioética, Animales de laboratorio, Modelos animales |
| Keyword: | Medical research, Bioethics, Laboratory animals, Animal models |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
