| Journal: | Revista de investigación clínica |
| Database: | PERIÓDICA |
| System number: | 000452982 |
| ISSN: | 0034-8376 |
| Authors: | Sosa Arellano, Matvey1 González Huerta, Norma C1 Morales Hernández, Eugenio2 Duarte Salazar, Carolina3 Miranda Duarte, Antonio1 |
| Institutions: | 1Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Departamento de Medicina Genómica, Ciudad de México. México 2Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Departamento de Radiología, Ciudad de México. México 3Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Servicio de Reumatología, Ciudad de México. México |
| Year: | 2022 |
| Season: | Mar-Abr |
| Volumen: | 74 |
| Number: | 2 |
| Pages: | 81-89 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Background: The association of leptin (LEP) and vascular endothelial growth factor A (VEGFA) genes with the susceptibility to knee osteoarthritis (OA) has been analyzed; however, the epistasis between them has not been investigated. Objective: The objective of the study was to analyze the association of LEP and VEGFA variants and their interaction with primary knee OA in a Mexican Mestizo population. Methods: A case-control study was developed. Cases were ≥40 years, BMI ≤27 kg/m2, with primary knee OA and radiologic Grade ≥2. Controls were participants with no knee OA and a radiologic Grade <2. The rs2167270 of LEP and rs2010963 of VEGFA were genotyped. Genotypic association was tested under codominant, dominant, and recessive models. Uni- and multi-variate analyses were developed through non-conditional logistic regression. The multifactor dimensionality reduction algorithm was developed to detect epistasis. Results: Participants comprised 103 cases and 179 controls. Allelic and genotypic distributions did not show differences between the groups. Notwithstanding, a statistically significant interaction was observed between the LEP and VEGFA genes (p = 0.02) with a testing accuracy of 0.5199 and cross-validation consistency of 10/10. This interaction model confers an increased risk to knee OA (OR [95% CI] = 1.8 [1.1-2.9]). Conclusion: Interaction between LEP and VEGFA is related with genetic susceptibility to developing primary knee OA |
| Disciplines: | Medicina |
| Keyword: | Reumatología, Osteoartritis, Leptina, Factor de crecimiento endotelial vascular, Variación genética, Epistasis |
| Keyword: | Rheumatology, Osteoarthritis, Leptin, Vascular endothelial growth factor, Genetic variation, Epistasis |
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