| Journal: | Revista de investigación clínica |
| Database: | PERIÓDICA |
| System number: | 000453068 |
| ISSN: | 0034-8376 |
| Authors: | Xu, Haiying1 Xu, Yizhou1 Yang, Jun1 Huang, Jinyu1 |
| Institutions: | 1Zhejiang Chinese Medical University, The Fourth Clinical Medical College, Hangzhou, Zhejiang. China |
| Year: | 2021 |
| Season: | May-Jun |
| Volumen: | 73 |
| Number: | 3 |
| Pages: | 138-144 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | The biomarker for left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) remains an unmet clinical need. The microRNA-30 (miR-30) family has been associated with LVH in cellular and animal studies, but not in a clinical setting. Objective: The objective of the study was to investigate the clinical significance of circulating levels of miR-30 family as a biomarker for LVH in EH patients. Methods: A total of 239 EH patients and 239 healthy controls were enrolled in this study. Circulating levels of miR-30 family members, namely, miR-30a, miR-30b, miR-30c-1, miR-30c-2, miR-30d, and miR-30e, were evaluated using real-time polymerase chain reaction assays. Results: The circulating miR-30a, miR-30b, and miR-30e were significantly reduced in EH patients in contrast to controls. EH patients with LVH (EH-LVH) had substantially lower circulating miR-30b and miR-30e levels compared to EH patients without LVH (EH-nLVH). Moreover, the expression levels of miR-30b and miR-30e were positively related to LVMI, respectively. Receiver operating curve analysis showed that circulating miR-30e levels distinguished EH patients from controls, and EH-LVH from EH-nLVH patients. Logistic regression analysis identified the circulating miR-30e as a risk factor for LVH in EH patients. Conclusion: Circulating miR-30e level can be used as a biomarker in distinguishing EH-LVH from EH-nLVH. A further prospective study is warranted to validate this finding |
| Disciplines: | Medicina |
| Keyword: | Sistema cardiovascular, Diagnóstico, Hipertensión esencial, Factores pronósticos, Hipertrofia ventricular izquierda, MicroARNs |
| Keyword: | Cardiovascular system, Diagnosis, Essential hypertension, Prognostic factors, Left ventricular hypertrophy, MicroRNAs |
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