Cardiovascular Risk Prediction Models in People Living with HIV in Colombia



Document title: Cardiovascular Risk Prediction Models in People Living with HIV in Colombia
Journal: Revista de investigación clínica
Database: PERIÓDICA
System number: 000452988
ISSN: 0034-8376
Authors: 1
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Institutions: 1Pontificia Universidad Javeriana, Facultad de Medicina, Bogotá. Colombia
2Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá. Colombia
Year:
Season: Ene-Feb
Volumen: 74
Number: 1
Pages: 23-30
Country: México
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract People living with HIV are at increased risk of cardiovascular disease. Cardiovascular risk (CVR) prediction scores are powerful tools for individualized assessment that inform decision-making about follow-up frequency, hypolipemiant treatment intensification, and choice antiretroviral therapy. Objectives: The objectives of the study were to evaluate the performance of multiple cardiovascular assessment scores in predicting major adverse cardiovascular events (MACE) at 5 and 10 years. Framingham (2004, 2008, and Colombia-adjusted), SCORE, PROCAM, ASCVD, and D:A:D scores were included in the analysis. Methods: Data were obtained from a medical registry of adults living with HIV attended by a teaching hospital in Colombia. All patients with complete information necessary for risk score calculations and determination of MACE at 5 and 10 years were included in the study. Receiver operating characteristic curves (ROC) were generated using calculations with all the aforementioned models for every individual. Differences between curves were compared with DeLong's test. Results: A total of 808 patients were included in the analysis. Mean age was 35 years, and 12% were female. The majority of subjects had low and very low CVR. Eight MACE occurred during follow-up. Area under ROC curves were: Framingham (0.90), Framingham ATP3 (0.92), Framingham calibrated for Colombia (0.90), SCORE (0.92), PROCAM (0.92), ASCVD (0.89), and D:A:D (0.92), with no statistically significant differences. Conclusions: The evaluated scores had an acceptable performance for HIV-infected patients in the studied cohort, especially for those in low and very low risk categories
Disciplines: Medicina
Keyword: Inmunología,
Virus,
Sistema cardiovascular,
VIH,
Riesgo cardiovascular,
Predicción
Keyword: Immunology,
Virus,
Cardiovascular system,
HIV,
Cardiovascular risk,
Prediction
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