| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452988 |
| ISSN: | 0034-8376 |
| Autors: | García Peña, Angel A1 De Vries, Esther1 Aldana Bitar, Jairo1 Cáceres, Edward1 Botero, Juan1 Vásquez Jiménez, Juan1 Tamara, Roberto1 Olejua, Peter2 |
| Institucions: | 1Pontificia Universidad Javeriana, Facultad de Medicina, Bogotá. Colombia 2Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá. Colombia |
| Any: | 2022 |
| Període: | Ene-Feb |
| Volum: | 74 |
| Número: | 1 |
| Paginació: | 23-30 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | People living with HIV are at increased risk of cardiovascular disease. Cardiovascular risk (CVR) prediction scores are powerful tools for individualized assessment that inform decision-making about follow-up frequency, hypolipemiant treatment intensification, and choice antiretroviral therapy. Objectives: The objectives of the study were to evaluate the performance of multiple cardiovascular assessment scores in predicting major adverse cardiovascular events (MACE) at 5 and 10 years. Framingham (2004, 2008, and Colombia-adjusted), SCORE, PROCAM, ASCVD, and D:A:D scores were included in the analysis. Methods: Data were obtained from a medical registry of adults living with HIV attended by a teaching hospital in Colombia. All patients with complete information necessary for risk score calculations and determination of MACE at 5 and 10 years were included in the study. Receiver operating characteristic curves (ROC) were generated using calculations with all the aforementioned models for every individual. Differences between curves were compared with DeLong's test. Results: A total of 808 patients were included in the analysis. Mean age was 35 years, and 12% were female. The majority of subjects had low and very low CVR. Eight MACE occurred during follow-up. Area under ROC curves were: Framingham (0.90), Framingham ATP3 (0.92), Framingham calibrated for Colombia (0.90), SCORE (0.92), PROCAM (0.92), ASCVD (0.89), and D:A:D (0.92), with no statistically significant differences. Conclusions: The evaluated scores had an acceptable performance for HIV-infected patients in the studied cohort, especially for those in low and very low risk categories |
| Disciplines | Medicina |
| Paraules clau: | Inmunología, Virus, Sistema cardiovascular, VIH, Riesgo cardiovascular, Predicción |
| Keyword: | Immunology, Virus, Cardiovascular system, HIV, Cardiovascular risk, Prediction |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
