| Revista: | RBM. Revista brasileira de medicina |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000317793 |
| ISSN: | 0034-7264 |
| Autores: | Nunes, Carlos Pereira1 Higashi, Rafael1 Ribeiro, Marcia Goncalves Fonseca, Adenilson de Souza da2 Leite, Ana Claudia Celestino Bezerra3 Krymchantowski, Abouch Valenty Nunes, Fabio Pereira4 Goldberg, Stephanie Wrobel |
| Instituciones: | 1Universidade Federal do Rio de Janeiro, Rio de Janeiro. Brasil 2Universidade do Estado do Rio de Janeiro, Rio de Janeiro. Brasil 3Fundacao Instituto Oswaldo Cruz, Instituto de Pesquisa Clinica Evandro Chagas, Rio de Janeiro. Brasil 4Massachusetts General Hospital, Boston, Massachusetts. Estados Unidos de América |
| Año: | 2008 |
| Periodo: | Ene-Feb |
| Volumen: | 65 |
| Número: | 1-2 |
| Paginación: | 15-21 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | in Group B received 2.5 mg cytidine 5'-{sodium P'(2-(trimethylammonio)-ethyl) hydrogen diphosphate}, and 1.5 mg uridine 5'-trisodium triphosphate in identical capsule forms. Main outcome measure: Primary outcome measures defined in the protocol included improvements in MCV, MCH and vitamin B12 reaching laboratory reference range, 3-point improvements in Global, Pain, and Paresthesia evaluations and a 20% reduction in VAS scores. Results: Normalization of laboratory evaluations occurred only in Group A. Three-point improvement in Global evaluation by the physician was observed only in Group A, while both groups showed improvement in Global evaluation by the patient. Patient's assessment of pain improved only in Group A, although VAS score decrease was noted in both groups both groups also had improvement in paresthesia evaluations. Vital signs did not change, while weight gain was observed in both groups. Adverse events seen in both groups included nausea, diarrhea, headache and abdominal cramps. Alterations in laboratory evaluations were reported in both groups, but could be directly attributed to anemia. Conclusion: The combination of vitamin B12, uridine and cytidine was found to be safe and effective in the treatment of the signs and symptoms of anemia in the population studied. The pain reduction observed in both groups may be attributed to activity of the nucleotides |
| Disciplinas: | Medicina |
| Palabras clave: | Metabolismo y nutrición, Terapéutica y rehabilitación, Anemia, Vitamina B12, Uridina, Citidina, Dolor, Neuropatías, Eficacia |
| Keyword: | Medicine, Metabolism and nutrition, Therapeutics and rehabilitation, Anemia, Vitamin B12, Uridine, Cytidine, Efficacy, Pain, Neuropathies |
| Solicitud del documento | |
