| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313220 |
| ISSN: | 0100-4042 |
| Authors: | Blau, Lorena1 Menegon, Renato Farina Chung, Man Chin |
| Institutions: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias Farmaceuticas, Araraquara, Sao Paulo. Brasil |
| Year: | 2006 |
| Season: | Nov |
| Volumen: | 29 |
| Number: | 6 |
| Pages: | 1307-1317 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives |
| Disciplines: | Química, Medicina |
| Keyword: | Química farmacéutica, Oncología, Profármacos, Cáncer, Activación enzimática, Quimioterapia |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Oncology, Prodrugs, Cancer, Enzymatic activation, Chemotherapy |
| Full text: | Texto completo (Ver HTML) |
