Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia



Título del documento: Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
Revista: Quimica nova
Base de datos: PERIÓDICA
Número de sistema: 000313220
ISSN: 0100-4042
Autors: 1

Institucions: 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias Farmaceuticas, Araraquara, Sao Paulo. Brasil
Any:
Període: Nov
Volum: 29
Número: 6
Paginació: 1307-1317
País: Brasil
Idioma: Portugués
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives
Disciplines Química,
Medicina
Paraules clau: Química farmacéutica,
Oncología,
Profármacos,
Cáncer,
Activación enzimática,
Quimioterapia
Keyword: Chemistry,
Medicine,
Medicinal chemistry,
Oncology,
Prodrugs,
Cancer,
Enzymatic activation,
Chemotherapy
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