| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313174 |
| ISSN: | 0100-4042 |
| Authors: | Goncalves, Marcos Moises1 Fraceto, Leonardo Fernandes Vila, Marta Maria Duarte Carvalho Oliveira, Robson Vicente Machado de |
| Institutions: | 1Universidade de Sorocaba, Sorocaba, Sao Paulo. Brasil |
| Year: | 2006 |
| Season: | Sep |
| Volumen: | 29 |
| Number: | 5 |
| Pages: | 1072-1077 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Polarizability correlates well with organic ion stabilization in solution and can be defined as a measure of the relative ease of the distortion of the electronic cloud of a dipolar system exposed to an external electric field. The effective atomic polarizability, alphad, has a fundamental influence on chemical reactivity in the gas phase and in solution. In terms of chemical reactivity the charge is generated within the molecule as a positive charge due to protonation, ionization or resulting from the attack of a nucleophilic anion. In this paper, lipoidal diaminedithiol (DADT) perfusion radioligands based on 99Tc m and possessing an alkylamine side chain have been used to check the influence of alphad on their brain uptake. Some new DADT derivatives, respectively DADT-DIPA (diaminedithiol - diisopropylamine), DADT DIBA (diaminedithiol diisobutylamine), DADT-PR (diaminedithiol - branched pyperidine), have been designed to have high nitrogen alkylamine alphad values. In spite of the fact of higher alphad values having been correlated to higher brain uptakes, there isn't a clear mechanism able to trap these radioligands into the brain space |
| Disciplines: | Química |
| Keyword: | Química orgánica, Polarizabilidad atómica, Radioligandos, Tecnecio 99m, Alquilaminas, Ionización |
| Keyword: | Chemistry, Organic chemistry, Atomic polarizability, Radioligands, Technetium 99m, Alkylamines, Ionization |
| Full text: | Texto completo (Ver HTML) |
