Polarizabilidade atômica efetiva alfad pode ditar a ionização de radioligantes 99Tc m - diaminoditiol alquilamínicos?



Título del documento: Polarizabilidade atômica efetiva alfad pode ditar a ionização de radioligantes 99Tc m - diaminoditiol alquilamínicos?
Revista: Quimica nova
Base de datos: PERIÓDICA
Número de sistema: 000313174
ISSN: 0100-4042
Autors: 1


Institucions: 1Universidade de Sorocaba, Sorocaba, Sao Paulo. Brasil
Any:
Període: Sep
Volum: 29
Número: 5
Paginació: 1072-1077
País: Brasil
Idioma: Portugués
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Polarizability correlates well with organic ion stabilization in solution and can be defined as a measure of the relative ease of the distortion of the electronic cloud of a dipolar system exposed to an external electric field. The effective atomic polarizability, alphad, has a fundamental influence on chemical reactivity in the gas phase and in solution. In terms of chemical reactivity the charge is generated within the molecule as a positive charge due to protonation, ionization or resulting from the attack of a nucleophilic anion. In this paper, lipoidal diaminedithiol (DADT) perfusion radioligands based on 99Tc m and possessing an alkylamine side chain have been used to check the influence of alphad on their brain uptake. Some new DADT derivatives, respectively DADT-DIPA (diaminedithiol - diisopropylamine), DADT DIBA (diaminedithiol diisobutylamine), DADT-PR (diaminedithiol - branched pyperidine), have been designed to have high nitrogen alkylamine alphad values. In spite of the fact of higher alphad values having been correlated to higher brain uptakes, there isn't a clear mechanism able to trap these radioligands into the brain space
Disciplines Química
Paraules clau: Química orgánica,
Polarizabilidad atómica,
Radioligandos,
Tecnecio 99m,
Alquilaminas,
Ionización
Keyword: Chemistry,
Organic chemistry,
Atomic polarizability,
Radioligands,
Technetium 99m,
Alkylamines,
Ionization
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