| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313408 |
| ISSN: | 0100-4042 |
| Authors: | Sena, Marcelo M1 Freitas, Camilla B Silva, Lucas C Perez, Caridad Noda Paula, Ydilla O. de |
| Institutions: | 1Universidade Estadual de Goias, Unidade Universitaria de Ciencias Exatas e Tecnologicas, Anapolis, Goias. Brasil |
| Year: | 2007 |
| Season: | Feb |
| Volumen: | 30 |
| Number: | 1 |
| Pages: | 75-79 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | A simple method was proposed for determination of paracetamol and ibuprofen in tablets, based on UV measurements and partial least squares. The procedure was performed at pH 10.5, in the concentration ranges 3.00-15.00 µg ml-1 (paracetamol) and 2.40-12.00 µg ml-1 (ibuprofen). The model was able to predict paracetamol and ibuprofen in synthetic mixtures with root mean squares errors of prediction of 0.12 and 0.17 µg ml-1, respectively. Figures of merit (sensitivity, limit of detection and precision) were also estimated. The results achieved for the determination of these drugs in pharmaceutical formulations were in agreement with label claims and verified by HPLC |
| Disciplines: | Química |
| Keyword: | Química analítica, Química farmacéutica, Formulaciones farmacéuticas, Acetaminofén, Control de calidad, Mínimos cuadrados parciales |
| Keyword: | Chemistry, Analytical chemistry, Medicinal chemistry, Pharmaceutical formulations, Acetaminophen, Quality control, Partial least squares |
| Full text: | Texto completo (Ver HTML) |
