| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313202 |
| ISSN: | 0100-4042 |
| Authors: | Melo, Eduardo Borges de1 Carvalho, Ivone2 |
| Institutions: | 1Universidade Estadual do Oeste do Parana, Colegiado de Farmacia, Cascavel, Parana. Brasil 2Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
| Year: | 2006 |
| Season: | Jul |
| Volumen: | 29 |
| Number: | 4 |
| Pages: | 840-843 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Glucosidases are involved in key steps in the processing of oligosaccharides by cleaving O-glucose residues. Since they catalyze breaking and transfer reactions of glucosidic groups for the normal growth and development of all the cells, defects or genetic deficiencies in these enzymes are associated with serious disorders of the carbohydrate metabolism. Thus, glucosidases represent important targets to develop inhibitors, owing to their potential activities against viruses, tumoral growth and metastasis, diabetes, Gaucher's disease and other syndromes associated with the lisosomal storage of glucoesphingolipids, and osteoarthritis. This paper presents a description of the biochemical pathways and mechanisms of alpha and beta-glucosidases, and the currently available drugs capable to inhibit these enzymes |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Alfa-glucosidasa, Beta-glucuronidasa, Desarrollo de fármacos, Diabetes, Enfermedad de Gaucher |
| Keyword: | Chemistry, Medicinal chemistry, Alpha-glycosidase, Beta-glycosidase, Drug development, Diabetes, Gaucher disease |
| Full text: | Texto completo (Ver HTML) |
