| Revista: | Mexican journal of medical research ICSA |
| Base de datos: | |
| Número de sistema: | 000583732 |
| ISSN: | 2007-5235 |
| Autores: | Romero Molina, María Asunción1 |
| Instituciones: | 1Universidad Autónoma del Estado de Hidalgo, |
| Año: | 2013 |
| Volumen: | 1 |
| Número: | 1 |
| País: | México |
| Idioma: | Español |
| Resumen en inglés | In the daily clinical practice, combined pharmacotherapy is often used when a single drug (monotherapy) treatment is not enough to relief moderate-severe pain in patients. The use of experimental animal models offers us great tools for the translation of data from animals to human. However, the accurate design of the preclinical study is a requisite to obtain valid outcomes. Using the isobolographic analysis we can easily establish differences between synergistic or additive responses expected from drug combinations, improving the management and treatment of pain. |
| Resumen en español | In the daily clinical practice, combined pharmacotherapy is often used when a single drug (monotherapy) treatment is not enough to relief moderate-severe pain in patients. The use of experimental animal models offers us great tools for the translation of data from animals to human. However, the accurate design of the preclinical study is a requisite to obtain valid outcomes. Using the isobolographic analysis we can easily establish differences between synergistic or additive responses expected from drug combinations, improving the management and treatment of pain. |
| Palabras clave: | Animal models, Analgesic Effects, Drug combination, Isobolographic Analysis. |
| Keyword: | Animal models, Analgesic Effects, Drug combination, Isobolographic Analysis. |
| Texto completo: | Texto completo (Ver HTML) |
