| Journal: | Mensaje bioquímico |
| Database: | PERIÓDICA |
| System number: | 000320764 |
| ISSN: | 0188-137X |
| Authors: | Docampo, Roberto1 |
| Institutions: | 1University of Georgia, Center for Tropical and Emerging Global Diseases, Athens, Georgia. Estados Unidos de América |
| Year: | 2008 |
| Season: | Ago |
| Volumen: | 32 |
| Pages: | 11-23 |
| Country: | México |
| Language: | Español |
| Document type: | Conferencia o discurso |
| Approach: | Experimental |
| Spanish abstract | Los gránulos de polifosfato fueron una de las primeras estructuras descritas en bacterias y se caracterizan por su alto contenido de fósforo en forma de polifosfato. Trabajos recientes han demostrado que los gránulos de polifosfato poseen una membrana limitante y tienen un mecanismo enzimático de acidificación. Su densidad electrónica, enriquecimiento en pirofosfato, polifosfato y cationes como calcio, magnesio y otros, son características en común con aquellas de organelos denominados acidocalcisomas en algunos eucariotes, desde protozoarios hasta plaquetas humanas, lo que indica que los acidocalcisomas evolucionaron antes de la separación de las líneas bacterianas y eucariotas. Se les han asignado diferentes funciones a los acidocalcisomas, entre ellas el depósito de cationes y fósforo, el metabolismo del polifosfato, la homeostasis del calcio, el mantenimiento del pH intracelular y la regulación osmótica |
| English abstract | One of the first subcellular structures described in bacteria were the polyphosphate granules, which are characterized by their high content of phosphorus in the form of polyphosphate. Recent work has shown that polyphosphate granules have a limiting membrane and possess an enzymatic mechanism for their acidification. Their electron density, enrichment in pyrophosphate, polyphosphate, and cations such as calcium, magnesium, and others, are characteristics in common with those of the organelles described as acidocalcisomes in a number of eukaryotic cells, from parasitic protists, to human platelets, indicating that acidocalcisomes evolved before the bacterial and eukaryotic lineages diverged. Acidocalcisomes have been linked with several functions, including storage of cations and phosphorus, polyphosphate metabolism, calcium homeostasis, maintenance of intracellular pH homeostasis, and osmoregulation |
| Disciplines: | Biología, Química |
| Keyword: | Biología celular, Protozoarios, Bioquímica, Acidocalcisomas, Ultraestructura, Polifosfatos, Pirofosfato |
| Keyword: | Biology, Chemistry, Cell biology, Protozoa, Biochemistry, Acidocalcisomes, Ultrastructure, Polyphosphates, Pyrophosphate |
| Full text: | Texto completo (Ver PDF) |
