| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452443 |
| ISSN: | 0074-0276 |
| Autores: | Kratz, Jadel M1 Gonçalves, Karolina R2 Romera, Lavínia M.D2 Moraes, Carolina Borsoi3 Bittencourt Cunha, Paula2 Schenkman, Sergio4 Chatelain, Eric1 Sosa Estani, Sergio1 |
| Instituciones: | 1Drugs for Neglected Diseases initiative, Ginebra. Suiza 2Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Sao Paulo. Brasil 3Universidade Federal de Sao Paulo, Departamento de Ciencias Farmaceuticas, Diadema, Sao Paulo. Brasil 4Universidade Federal de Sao Paulo, Departamento de Microbiologia, Imunologia e Parasitologia, Sao Paulo. Brasil |
| Año: | 2022 |
| Volumen: | 117 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, prospectivo |
| Resumen en inglés | Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease |
| Disciplinas: | Medicina |
| Palabras clave: | Parasitología, Farmacología, Enfermedad de Chagas, Modelos animales, Desarrollo de fármacos, Farmacodinamia, Trypanosoma cruzi |
| Keyword: | Parasitology, Pharmacology, Chagas disease, Animal models, Drug development, Pharmacodynamics, Trypanosoma cruzi |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
