Serial measurement of the circulating levels of tumour necrosis factor and its soluble receptors 1 and 2 for monitoring leprosy patients during multidrug treatment
Document title: Serial measurement of the circulating levels of tumour necrosis factor and its soluble receptors 1 and 2 for monitoring leprosy patients during multidrug treatment
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000370918
ISSN: 0074-0276
Authors: 1
2
3
4
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5
1
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7
Institutions: 1Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte, Minas Gerais. Brasil
2Universidade Federal dos Vales do Jequitinhonha e Mucuri, Laboratorio de Inflamacao e Metabolismo, Diamantina, Minas Gerais. Brasil
3Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil
4Fundacao Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes, Belo Horizonte, Minas Gerais. Brasil
5Universidade Jose do Rosario Vellano, Alfenas, Minas Gerais. Brasil
6Universidade Federal de Alfenas, Alfenas, Minas Gerais. Brasil
7Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, Minas Gerais. Brasil
Year:
Season: Dic
Volumen: 108
Number: 8
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host response to the aetiologic agent, Mycobacterium leprae . The induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, primarily through the action of cytokines. The purpose of the present study was to evaluate the serum levels of tumour necrosis factor (TNF)-α and its soluble receptors (sTNF-R1 and sTNF-R2) in leprosy patients at different stages of multidrug treatment (MDT) in comparison with non-infected individuals and to determine their role as putative biomarkers of the severity of leprosy or the treatment response. ELISA was used to measure the levels of these molecules in 30 healthy controls and 37 leprosy patients at the time of diagnosis and during and after MDT. Our results showed increases in the serum levels of TNF-α and sTNF-R2 in infected individuals in comparison with controls. The levels of TNF-α, but not sTNF-R2, decreased with treatment. The current results corroborate previous reports of elevated serum levels of TNF-α in leprosy and suggest a role for sTNF-R2 in the control of this cytokine during MDT
Disciplines: Medicina
Keyword: Dermatología,
Diagnóstico,
Microbiología,
Lepra,
Factor de necrosis tumoral,
Marcadores moleculares
Keyword: Medicine,
Dermatology,
Diagnosis,
Microbiology,
Leprosy,
Tumor necrosis factor,
Molecular markers
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