Revista: | Memorias do Instituto Oswaldo Cruz |
Base de datos: | PERIÓDICA |
Número de sistema: | 000370918 |
ISSN: | 0074-0276 |
Autors: | Costa, Rosane Dias1 Mendonca, Vanessa Amaral2 Soriani, Frederico Marianetti3 Lyon, Sandra4 Penido, Rachel Adriana4 Costa, Ana Maria Duarte Dias5 Costa, Marina Dias1 Terra, Fabio de Souza6 Teixeira, Mauro Martins7 Antunes, Carlos Mauricio de Figueiredo1 Teixeira, Antonio Lucio7 |
Institucions: | 1Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal dos Vales do Jequitinhonha e Mucuri, Laboratorio de Inflamacao e Metabolismo, Diamantina, Minas Gerais. Brasil 3Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 4Fundacao Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes, Belo Horizonte, Minas Gerais. Brasil 5Universidade Jose do Rosario Vellano, Alfenas, Minas Gerais. Brasil 6Universidade Federal de Alfenas, Alfenas, Minas Gerais. Brasil 7Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, Minas Gerais. Brasil |
Any: | 2013 |
Període: | Dic |
Volum: | 108 |
Número: | 8 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host response to the aetiologic agent, Mycobacterium leprae . The induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, primarily through the action of cytokines. The purpose of the present study was to evaluate the serum levels of tumour necrosis factor (TNF)-α and its soluble receptors (sTNF-R1 and sTNF-R2) in leprosy patients at different stages of multidrug treatment (MDT) in comparison with non-infected individuals and to determine their role as putative biomarkers of the severity of leprosy or the treatment response. ELISA was used to measure the levels of these molecules in 30 healthy controls and 37 leprosy patients at the time of diagnosis and during and after MDT. Our results showed increases in the serum levels of TNF-α and sTNF-R2 in infected individuals in comparison with controls. The levels of TNF-α, but not sTNF-R2, decreased with treatment. The current results corroborate previous reports of elevated serum levels of TNF-α in leprosy and suggest a role for sTNF-R2 in the control of this cytokine during MDT |
Disciplines | Medicina |
Paraules clau: | Dermatología, Diagnóstico, Microbiología, Lepra, Factor de necrosis tumoral, Marcadores moleculares |
Keyword: | Medicine, Dermatology, Diagnosis, Microbiology, Leprosy, Tumor necrosis factor, Molecular markers |
Text complet: | Texto completo (Ver HTML) |