Prevalence of hepatitis C virus and human immunodeficiency virus in a group of patients newly diagnosed with active tuberculosis in Porto Alegre, Southern Brazil
Document title: Prevalence of hepatitis C virus and human immunodeficiency virus in a group of patients newly diagnosed with active tuberculosis in Porto Alegre, Southern Brazil
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000405457
ISSN: 0074-0276
Authors: 1
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2
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Institutions: 1Secretaria Estadual da Saude do Rio Grande do Sul, Fundacao Estadual de Producao e Pesquisa em Saude, Porto Alegre, Rio Grande do Sul. Brasil
2Universidade Luterana do Brasil, Canoas, Rio Grande do Sul. Brasil
3Universidade de Santa Cruz do Sul, Programa de Pos-Graduacao em Promocao da Saude, Santa Cruz do Sul, Rio Grande do Sul. Brasil
4Secretaria Estadual da Saude do Rio Grande do Sul, Hospital Sanatorio Partenon, Porto Alegre, Rio Grande do Sul. Brasil
5Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil
Year:
Season: Abr
Volumen: 112
Number: 4
Pages: 255-259
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and the highest proportion of people infected with human immunodeficiency virus (HIV) among patients with TB. Hepatitis C virus (HCV) infection increases the risk of anti-TB drug-induced hepatotoxicity, which may result in discontinuation of the therapy. OBJECTIVES The aim of this study was (i) to estimate prevalence of HCV and HIV in a group of patients newly diagnosed with active TB in a public reference hospital in Porto Alegre and (ii) to compare demographic, behavioural, and clinical characteristics of patients in relation to their HCV infection status. METHODS One hundred and thirty-eight patients with TB were tested for anti-HCV antibody, HCV RNA, and anti-HIV1/2 antibody markers. HCV RNA from real-time polymerase chain reaction (PCR)-positive samples was submitted to reverse transcription and PCR amplification. The 5′ non-coding region of the HCV genome was sequenced, and genotypes of HCV isolates were determined. FINDINGS Anti-HCV antibody, HCV RNA, and anti-HIV antibodies were detected in 27 [20%; 95% confidence interval (CI), 13-26%], 17 (12%; 95% CI, 7-18%), and 34 (25%; 95% CI, 17-32%) patients, respectively. HCV isolates belonged to genotypes 1 (n = 12) and 3 (n = 4). Some characteristics were significantly more frequent in patients infected with HCV. Among them, non-white individuals, alcoholics, users of illicit drugs, imprisoned individuals, and those with history of previous TB episode were more commonly infected with HCV (p < 0.05). MAIN CONCLUSIONS HCV screening, including detection of anti-HCV antibody and HCV RNA, will be important to improving the management of co-infected patients, given their increased risk of developing TB treatment-related hepatotoxicity
Disciplines: Medicina
Keyword: Microbiología,
Inmunología,
Epidemiología,
Prevalencia,
Virus de la hepatitis C,
VIH,
Tuberculosis,
Coinfecciones,
Genotipos
Keyword: Medicine,
Microbiology,
Immunology,
Epidemiology,
Prevalence,
Hepatitis C virus,
HIV,
Tuberculosis,
Coinfections,
Genotypes
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