Revista: | Memorias do Instituto Oswaldo Cruz |
Base de datos: | PERIÓDICA |
Número de sistema: | 000405457 |
ISSN: | 0074-0276 |
Autores: | Costi, Cintia1 Grandi, Tarciana1 Halon, Maria Laura1 Silva, Marcia Susana Nunes2 Silva, Claudia Maria Dornelles da1 Gregianini, Tatiana Schaffer1 Possuelo, Lia Goncalves3 Jarczewski, Carla Adriane4 Niel, Christian5 Rossetti, Maria Lucia Rosa1 |
Instituciones: | 1Secretaria Estadual da Saude do Rio Grande do Sul, Fundacao Estadual de Producao e Pesquisa em Saude, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Luterana do Brasil, Canoas, Rio Grande do Sul. Brasil 3Universidade de Santa Cruz do Sul, Programa de Pos-Graduacao em Promocao da Saude, Santa Cruz do Sul, Rio Grande do Sul. Brasil 4Secretaria Estadual da Saude do Rio Grande do Sul, Hospital Sanatorio Partenon, Porto Alegre, Rio Grande do Sul. Brasil 5Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil |
Año: | 2017 |
Periodo: | Abr |
Volumen: | 112 |
Número: | 4 |
Paginación: | 255-259 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and the highest proportion of people infected with human immunodeficiency virus (HIV) among patients with TB. Hepatitis C virus (HCV) infection increases the risk of anti-TB drug-induced hepatotoxicity, which may result in discontinuation of the therapy. OBJECTIVES The aim of this study was (i) to estimate prevalence of HCV and HIV in a group of patients newly diagnosed with active TB in a public reference hospital in Porto Alegre and (ii) to compare demographic, behavioural, and clinical characteristics of patients in relation to their HCV infection status. METHODS One hundred and thirty-eight patients with TB were tested for anti-HCV antibody, HCV RNA, and anti-HIV1/2 antibody markers. HCV RNA from real-time polymerase chain reaction (PCR)-positive samples was submitted to reverse transcription and PCR amplification. The 5′ non-coding region of the HCV genome was sequenced, and genotypes of HCV isolates were determined. FINDINGS Anti-HCV antibody, HCV RNA, and anti-HIV antibodies were detected in 27 [20%; 95% confidence interval (CI), 13-26%], 17 (12%; 95% CI, 7-18%), and 34 (25%; 95% CI, 17-32%) patients, respectively. HCV isolates belonged to genotypes 1 (n = 12) and 3 (n = 4). Some characteristics were significantly more frequent in patients infected with HCV. Among them, non-white individuals, alcoholics, users of illicit drugs, imprisoned individuals, and those with history of previous TB episode were more commonly infected with HCV (p < 0.05). MAIN CONCLUSIONS HCV screening, including detection of anti-HCV antibody and HCV RNA, will be important to improving the management of co-infected patients, given their increased risk of developing TB treatment-related hepatotoxicity |
Disciplinas: | Medicina |
Palabras clave: | Microbiología, Inmunología, Epidemiología, Prevalencia, Virus de la hepatitis C, VIH, Tuberculosis, Coinfecciones, Genotipos |
Keyword: | Medicine, Microbiology, Immunology, Epidemiology, Prevalence, Hepatitis C virus, HIV, Tuberculosis, Coinfections, Genotypes |
Texto completo: | Texto completo (Ver HTML) |