| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000459482 |
| ISSN: | 0074-0276 |
| Authors: | Sousa-Junior, Ivanildo Pedro1 Vieira, Tuane Cristine Ramos Gonçalves2 |
| Institutions: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Universidade Federal do Rio de Janeiro, Instituto Nacional de Ciencia e Tecnologia em Biologia Estrutural e Bioimagem, Rio de Janeiro. Brasil |
| Year: | 2023 |
| Volumen: | 118 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Neurodegenerative diseases (NDs) are increasingly common, especially in populations with higher life expectancies. They are associated mainly with protein metabolism and structure changes, leading to neuronal cell death. Viral infections affect these cellular processes and may be involved in the etiology of several neurological illnesses, particularly NDs. Enteroviruses (EVs) frequently infect the central nervous system (CNS), causing neurological disease. Inflammation, disruption of the host autophagy machinery, and deregulation and accumulation/misfolding of proteins are the main alterations observed after infection by an EV. In this perspective, we discuss the most recent findings on the subject, examining the possible role of EVs in the development of NDs, and shedding light on the putative role played by these viruses in developing NDs |
| Disciplines: | Medicina |
| Keyword: | Neurología, Virus, Enterovirus, Enfermedades neurodegenerativas, Esclerosis lateral amiotrófica, Enfermedad de Alzheimer, Enfermedad de Parkinson |
| Keyword: | Neurology, Virus, Enterovirus, Neurodegenerative diseases, Amyotrophic lateral sclerosis, Alzheimer disease, Parkinson disease |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
