| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452407 |
| ISSN: | 0074-0276 |
| Authors: | Germano, Giovanna Valle1 Braga, André Flores1 Camargo, Rodrigo Mendes de1 Ballalai, Priscila Betoni2 Bezerra, Ohanna Cavalcanti3 Manta, Fernanda Saloum de Neves3 Belone, Andréa de Faria Fernandes2 Soares, Cleverson Teixeira2 Das, Pranab Kumar4 Moraes, Milton Ozório3 Latini, Ana Carla Pereira2 Brito de Souza, Vânia Niéto2 |
| Institutions: | 1Faculdade de Medicina de Botucatu, Programa de Pos-graduacao em Doencas Tropicais, Botucatu, Sao Paulo. Brasil 2Secretaria de Saude do Estado de Sao Paulo, Instituto Lauro de Souza Lima, Bauru, Sao Paulo. Brasil 3Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 4University of Birmingham, College of Medical and Dental Sciences, Edgbaston, Birmingham. Reino Unido |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | BACKGROUND Leprosy, caused by Mycobacterium leprae, is a public health problem in Brazil that affects peripheral nerves, resulting in physical disabilities. During host-pathogen interactions, the immune response determines leprosy outcomes from a localised (paucibacillary) form to a disseminated (multibacillary) form. The recognition of M. leprae involves the DC-SIGN receptor, which is present on the dendritic cells (DCs) and participates in immune activation. OBJECTIVES To evaluate the association of polymorphisms in the promoter region of the gene encoding DC-SIGN (CD209) and the clinical form of leprosy, and to investigate its functional effects. METHODS The study population included 406 leprosy patients from an endemic area in Brazil [310 multibacillary (MB); 96 paucibacillary (PB)]. A functional evaluation based on the effects of the single nucleotide variant (SNV) associated with PB leprosy on the specific immune response was also performed. RESULTS The GA genotype and the presence of the A allele of rs735240 (-939G>A) were associated with PB leprosy [OR: 2.09 (1.18-3.69) and 1.84 (1.07-3.14), respectively]. Carriers of the A allele showed reduced expression of CD209 and TGF-β1 in leprosy lesions in comparison with individuals with GG genotype, in addition to a higher response to the Mitsuda test. CONCLUSION These data suggest that rs735240 influences the immune response against M. leprae and clinical presentation of leprosy |
| Disciplines: | Medicina |
| Keyword: | Dermatología, Parasitología, Lepra, Polimorfismos de nucleótido único (SNPs), Mycobacterium leprae |
| Keyword: | Dermatology, Parasitology, Leprosy, Single nucleotide polymorphism (SNPs), Mycobacterium leprae |
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