Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
Document title: Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000452430
ISSN: 0074-0276
Authors: 1
1
Institutions: 1Fundacao Oswaldo Cruz, Instituto Rene Rachou, Belo Horizonte, Minas Gerais. Brasil
Year:
Volumen: 117
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Chagas disease and leishmaniasis are neglected tropical diseases caused by the protozoan parasites Trypanosoma cruzi and Leishmania spp., respectively. They are among the most important parasitic diseases, affecting millions of people worldwide, being a considerable global challenge. However, there is no human vaccine available against T. cruzi and Leishmania infections, and their control is based mainly on chemotherapy. Treatments for Chagas disease and leishmaniasis have multiple limitations, mainly due to the high toxicity of the available drugs, long-term treatment protocols, and the occurrence of drug-resistant parasite strains. In the case of Chagas disease, there is still the problem of low cure rates in the chronic stage of the disease. Therefore, new therapeutic agents and novel targets for drug development are urgently needed. Antioxidant defence in Trypanosomatidae is a potential target for chemotherapy because the organisms present a unique mechanism for trypanothione-dependent detoxification of peroxides, which differs from that found in vertebrates. Cellular thiol redox homeostasis is maintained by the biosynthesis and reduction of trypanothione, involving different enzymes that act in concert. This study provides an overview of the antioxidant defence focusing on iron superoxide dismutase A, tryparedoxin peroxidase, and ascorbate peroxidase and how the enzymes play an important role in the defence against oxidative stress and their involvement in drug resistance mechanisms in T. cruzi and Leishmania spp
Disciplines: Medicina
Keyword: Parasitología,
Farmacología,
Enfermedad de Chagas,
Leishmaniasis,
Quimioterapia,
Antioxidantes,
Resistencia a fármacos
Keyword: Parasitology,
Pharmacology,
Chagas diseases,
Leishmaniasis,
Chemotherapy,
Antioxidants,
Drug resistance
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