| Journal: | Journal of the Mexican Chemical Society |
| Database: | PERIÓDICA |
| System number: | 000368008 |
| ISSN: | 1665-9686 |
| Authors: | https://biblat.unam.mx/en/frecuencias/autor1 López Ruiz, Heraclio1 Rojas Lima, Susana1 Alvarez Hernández, Alejandro1 Tapia Benavides, Rafael1 García López, María Concepción1 |
| Institutions: | 1Universidad Autónoma del Estado de Hidalgo, Area Académica de Química, Mineral de la Reforma, Hidalgo. México |
| Year: | 2011 |
| Season: | Jul-Sep |
| Volumen: | 55 |
| Number: | 3 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| Spanish abstract | Derivados quirales novedosos de glicinato (S)–6 y (S)–7 conteniendo el grupo α–feniletil fueron preparados y estudiados como precursores potenciales de α–aminoácidos α–sustituidos. En particular el auxiliar quiral N–(l–feniletil)benzamida mostró estereoinducción sustancial (78:22 dr) en la alquilación del enolato (S)–7–Li. La adición de DMPU no mostró un efecto apreciable en la diastereoselectividad |
| English abstract | Novel chiral glycinate derivatives (S)–6 and (S)–7 containing the α–phenylethyl group, were prepared and studied as potential precursors of enantiopure α–substituted–α–amino acids. In particular, the alkylation of enolate (S)–7–Li showed substantial (78:22 dr) stereoinduction by the N–(l–phenylethyl)benzamide chiral auxiliary. Addition of DMPU showed no appreciable effect upon the diastereoselectivity |
| Disciplines: | Química |
| Keyword: | Química orgánica, Enolatos de litio, Glicinato, Alquilación diastereoselectiva, Aminoácidos |
| Keyword: | Chemistry, Organic chemistry, Lithium enolates, Glycinate, Diastereoselective alkylation, Amino acids |
| Full text: | Texto completo (Ver HTML) |
