| Journal: | Jornal brasileiro de pneumologia |
| Database: | PERIÓDICA |
| System number: | 000297436 |
| ISSN: | 1806-3713 |
| Authors: | Brito, Rossana Coimbra1 Gounder, Celine Lima, Dirce Bonfim de Siqueira, Helio Cavalcanti, Hebe Rodrigues Pereira, Maracy Marques Kritski, Afranio Lineu |
| Institutions: | 1Universidade Federal do Rio de Janeiro, Rio de Janeiro. Brasil |
| Year: | 2004 |
| Season: | Jul-Ago |
| Volumen: | 30 |
| Number: | 4 |
| Pages: | 335-342 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | BACKGROUND:Tuberculosis become important challenge to health care settings. Brazil has high prevalence of the disease and Rio de Janeiro has high incidence rates with 30% of cases notified at hospitals. OBJECTIVE: To evaluate prevalence of initial and acquired drug resistance at a general hospital, reference for aids treatment in Rio de Janeiro and to identify associated factors. METHODS: Mycobacterium tuberculosis strains from 165 patients were analyzed, between August 1996 and February 1998. RESULTS: Twenty per cent (33/165) were resistant to at least one drug; 13% (12/165) to isoniazid; 3.64% (6/165) to rifampin and 3.64% (6/165) to both. Among HIV seropositive subjects (52/165); 28.85% (15/52) were resistant to at least one drug. Acquired resistance occurred in 15.79% of 19 patients that mentioned previous antiTB treatment. Association statistically significant was found with non cavitation on X-ray in bivariate analyses (P=0.05). Eighty four patients refereed no previous treatment (NPT). Resistance to 1 or more drugs was found in 28.57% (24/84) of NPT patients. Association statistically significant with initial resistance was found with health care workers (P=0.004), unemployment (P=0.03), and diarrhea (P=0.01) in bivariate analyses. On multivariate analyses, health care workers (P=0.002) remained significantly associated with initial resistance. CONCLUSIONS: High resistance rates was found. It corroborates that hospitals needs attention for TB control especially which concerns to health care works infection |
| Portuguese abstract | CONCLUSÃO: Taxas de resistência elevadas foram encontradas nesta série. Estes achados corroboram a necessidade de que atenção maior seja dada à tuberculose em ambiente hospitalar, em especial no que diz respeito à preocupante associação entre resistência nas cepas isoladas e profissionais de saúde |
| Disciplines: | Medicina |
| Keyword: | Hospitales, Neumología, Salud pública, Terapéutica y rehabilitación, Mycobacterium tuberculosis, Enfermedades trasmisibles, Resistencia a fármacos, Antimicrobianos, VIH |
| Keyword: | Medicine, Hospitals, Pneumology, Public health, Therapeutics and rehabilitation, Mycobacterium tuberculosis, Communicable diseases, Drug resistance, Antimicrobial agents, HIV |
| Full text: | Texto completo (Ver HTML) |
