Resistencia aos medicamentos anti-tuberculose de cepas de Mycobacterium tuberculosis isoladas de pacientes atendidos em hospital geral de referencia para tratamento de AIDS no Rio de Janeiro



Título del documento: Resistencia aos medicamentos anti-tuberculose de cepas de Mycobacterium tuberculosis isoladas de pacientes atendidos em hospital geral de referencia para tratamento de AIDS no Rio de Janeiro
Revista: Jornal brasileiro de pneumologia
Base de datos: PERIÓDICA
Número de sistema: 000297436
ISSN: 1806-3713
Autors: 1





Institucions: 1Universidade Federal do Rio de Janeiro, Rio de Janeiro. Brasil
Any:
Període: Jul-Ago
Volum: 30
Número: 4
Paginació: 335-342
País: Brasil
Idioma: Portugués
Tipo de documento: Artículo
Enfoque: Caso clínico, analítico
Resumen en inglés BACKGROUND:Tuberculosis become important challenge to health care settings. Brazil has high prevalence of the disease and Rio de Janeiro has high incidence rates with 30% of cases notified at hospitals. OBJECTIVE: To evaluate prevalence of initial and acquired drug resistance at a general hospital, reference for aids treatment in Rio de Janeiro and to identify associated factors. METHODS: Mycobacterium tuberculosis strains from 165 patients were analyzed, between August 1996 and February 1998. RESULTS: Twenty per cent (33/165) were resistant to at least one drug; 13% (12/165) to isoniazid; 3.64% (6/165) to rifampin and 3.64% (6/165) to both. Among HIV seropositive subjects (52/165); 28.85% (15/52) were resistant to at least one drug. Acquired resistance occurred in 15.79% of 19 patients that mentioned previous antiTB treatment. Association statistically significant was found with non cavitation on X-ray in bivariate analyses (P=0.05). Eighty four patients refereed no previous treatment (NPT). Resistance to 1 or more drugs was found in 28.57% (24/84) of NPT patients. Association statistically significant with initial resistance was found with health care workers (P=0.004), unemployment (P=0.03), and diarrhea (P=0.01) in bivariate analyses. On multivariate analyses, health care workers (P=0.002) remained significantly associated with initial resistance. CONCLUSIONS: High resistance rates was found. It corroborates that hospitals needs attention for TB control especially which concerns to health care works infection
Resumen en portugués CONCLUSÃO: Taxas de resistência elevadas foram encontradas nesta série. Estes achados corroboram a necessidade de que atenção maior seja dada à tuberculose em ambiente hospitalar, em especial no que diz respeito à preocupante associação entre resistência nas cepas isoladas e profissionais de saúde
Disciplines Medicina
Paraules clau: Hospitales,
Neumología,
Salud pública,
Terapéutica y rehabilitación,
Mycobacterium tuberculosis,
Enfermedades trasmisibles,
Resistencia a fármacos,
Antimicrobianos,
VIH
Keyword: Medicine,
Hospitals,
Pneumology,
Public health,
Therapeutics and rehabilitation,
Mycobacterium tuberculosis,
Communicable diseases,
Drug resistance,
Antimicrobial agents,
HIV
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