| Journal: | International braz j urol |
| Database: | PERIÓDICA |
| System number: | 000296817 |
| ISSN: | 1677-5538 |
| Authors: | Santucci, Richard A1 Barber, Theodore D |
| Institutions: | 1Wayne State University, School of Medicine, Detroit, Michigan. Estados Unidos de América |
| Year: | 2005 |
| Season: | May-Jun |
| Volumen: | 31 |
| Number: | 3 |
| Pages: | 192-203 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Teórico, descriptivo |
| English abstract | PURPOSE: There is an increasingly large body of literature concerning tissue-engineering products that may be used in urology. Some of these are quite complex (such as multilayer patient-specific cell-seeded implants) yet the most simple and successful products to date are also the most uncomplicated: resorbable acellular extra-cellular matrices (ECMs) harvested from animals. ECMs have been used in a variety of difficult urologic reconstruction problems, and this review is intended to summarize this complex literature for the practicing urologist. METHODS: Medline search of related terms such as "SIS, small intestinal submucosa, ECM, extracellular matrix, acellular matrix and urologic reconstruction". Manuscripts missed in the initial search were taken from the bibliographies of the primary references. RESULTS: Full review of potential clinical uses of resorbable extra-cellular matrices in urologic reconstruction. CONCLUSIONS: Currently, the "state of the art" in tissue engineering solutions for urologic reconstruction means resorbable acellular xenograft matrices. They show promise when used as a pubovaginal sling or extra bolstering layers in ureteral or urethral repairs, although recent problems with inflammation following 8-ply pubovaginal sling use and failures after 1- and 4-ply SIS repair of Peyronie's disease underscore the need for research before wide adoption. Preliminary data is mixed concerning the potential for ECM urethral patch graft, and more data is needed before extended uses such as bladder a |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Cirugía reconstructiva, Intestino delgado, Matriz extracelular, Injertos, Mucosa intestinal |
| Keyword: | Medicine, Surgery, Reconstructive surgery, Small intestine, Extracellular matrix, Grafts, Intestinal mucosa |
| Full text: | Texto completo (Ver HTML) |
