Revista: | International braz j urol |
Base de datos: | PERIÓDICA |
Número de sistema: | 000296743 |
ISSN: | 1677-5538 |
Autores: | Billis, Athanase1 Magna, Luis A Lira, Mariana M Moreira, Luciana R Okamura, Helio Paz, Alexandre R Perina, Rita C Triglia, Renata M Ferreira, Ubirajara |
Instituciones: | 1Universidade Estadual de Campinas, Escuela de Medicina, Campinas, Sao Paulo. Brasil |
Año: | 2005 |
Periodo: | Nov-Dic |
Volumen: | 31 |
Número: | 6 |
Paginación: | 534-540 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Caso clínico, analítico |
Resumen en inglés | OBJECTIVE: It is controversial whether age is associated with higher grade and worse outcome. Some studies have not found age to be related to outcome nor younger age to be associated with better response to therapy. MATERIALS AND METHODS: The study population consisted of 27 patients aged 55 years or younger and 173 patients 56 years or older submitted to radical prostatectomy. The variables studied were preoperative PSA, time to PSA progression following radical prostatectomy and pathologic findings in surgical specimens: Gleason score, Gleason predominant grade, positive surgical margins, tumor extent, extraprostatic extension (pT3a), and seminal vesicle invasion (pT3b). RESULTS: Comparing patients aged 55 years or younger and 56 years or older, there was no statistically significant difference for all variables studied: preoperative PSA (p = 0.4417), Gleason score (p = 0.3934), Gleason predominant grade (p = 0.2653), tumor extent (p = 0.1190), positive surgical margins (p = 0.8335), extraprostatic extension (p = 0.3447) and seminal vesicle invasion (p > 0.9999). During the study period, 44 patients (22%) developed PSA progression. No difference was found in the time to biochemical progression between men aged 55 years or younger and 56 years or older. CONCLUSION: Our findings suggest that age alone do not influence the biological aggressiveness of prostate cancer |
Disciplinas: | Medicina |
Palabras clave: | Cirugía, Oncología, Próstata, Neoplasias, Antígeno prostático específico, Prostatectomía, Patología, Edad, Factores de riesgo |
Keyword: | Medicine, Oncology, Surgery, Prostate, Neoplasms, Prostate specific antigen, Prostatectomy, Pathology, Age, Risk factors |
Texto completo: | Texto completo (Ver HTML) |