| Journal: | International braz j urol |
| Database: | PERIÓDICA |
| System number: | 000296990 |
| ISSN: | 1677-5538 |
| Authors: | Skalova, Sylva1 Rejtar, Pavel Kutilek, Stepan |
| Institutions: | 1Charles University, Department of Pediatrics, Hradec Králové. República Checa |
| Year: | 2007 |
| Season: | Ene-Feb |
| Volumen: | 33 |
| Number: | 1 |
| Pages: | 80-86 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | OBJECTIVE: Hydronephrosis leads to deterioration of renal function. As urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activity is considered a sensitive marker of renal tubular impairment, our aim was to measure U-NAG in children with hydronephrosis and to look for a relationship among selected clinical parameters. MATERIALS AND METHODS: We studied 31 children (22 boys and 9 girls, mean age 2.3 ± 2.5 years) with hydronephrosis grade 1-4 that had U-NAG/creatinine ratio (U-NAG/Cr) measured. RESULTS: The U-NAG/Cr was significantly higher in patients with hydronephrosis compared to reference data (p = 0.002). There was no difference in U-NAG/Cr between children with unilateral and bilateral hydronephrosis (p = 0.51). There was no significant difference in U-NAG/Cr between children with grades 1-3 (pooled data) and grade 4, respectively (p = 0.89). There was no correlation between U-NAG/Cr and the grade of hydronephrosis (r = 0.01). CONCLUSIONS: U-NAG/Cr is increased in children with hydronephrosis grade 1-4, and there is no relationship with the grade of hydronephrosis. U-NAG is a useful marker of renal tubular dysfunction, however its relationship with the degree of kidney damage in patients with hydronephrosis should be considered as doubtful |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Nefrología, Pediatría, Hidronefrosis, Niños, Acetilglucosaminidasa |
| Keyword: | Medicine, Nephrology, Pediatrics, Surgery, Hydronephrosis, Children, acethyl-glucosaminidase |
| Full text: | Texto completo (Ver HTML) |
