| Journal: | International braz j urol |
| Database: | PERIÓDICA |
| System number: | 000434646 |
| ISSN: | 1677-5538 |
| Authors: | Olcucu, Mahmut Taha1 Teke, Kerem1 Yildirim, Kadir2 Togac, Mesut3 Isik, Burcu3 Yilmaz, Yusuf Cem3 |
| Institutions: | 1Agri State Hospital, Department of Urology, Agri. Turquía 2Elazig Education and Research Hospital, Department of Urology, Elazig. Turquía 3Agri State Hospital, Department of Ophthalmology, Agri. Turquía |
| Year: | 2020 |
| Season: | Mar-Abr |
| Volumen: | 46 |
| Number: | 2 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Objective To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD). Materials and Methods Patients with overactive bladder (OAB) diagnosed according to The International Continence Society were administered with solifenacin, darifenacin or propiverine on a daily basis between November 2017 and May 2018. NCT, SFCT, TCT, IOP, and PD of these patients were measured and compared as initial, fourth and twelfth weeks. Results A total of 165 patients (330 eyes) with OAB were evaluated. Solifenacin (n=140) significantly reduced IOP from 17.30±2.72 mmHg to 16.67±2.56 mmHg (p=0.006) and 16.57±2.41 mmHg (p=0.002), at the fourth and twelfth weeks, respectively. Darifenacin (n=110) significantly reduced NCT from 258.70±23.96 μm to 257.51±22.66 μm (p=0.002) and 255.36±19.69 μm (p=0.038), at the fourth and twelfth weeks, respectively. Propiverine (n=80) significantly increased PD from 4.04±0.48 mm to 4.08±0.44 mm (p=0.009) and 4.09±0.45 mm (p=0.001), at the fourth and twelfth weeks, respectively. Conclusion These findings can help to decide appropriate anticholinergic drug choice in OAB patients. We finally suggest further well-designed randomized prospective studies with a larger population to evaluate the anticholinergic-related complications in eyes |
| Disciplines: | Medicina |
| Keyword: | Urología, Farmacología, Oftalmología, Vejiga hiperactiva, Solifenacin, Darifenacin, Propiverina, Efectos laterales, Presión intraocular, Anisocoria |
| Keyword: | Urology, Pharmacology, Ophthalmology, Overactive bladder, Solifenacin, Darifenacin, Propiverine, Side effects, Intraocular pressure, Anisocoria |
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