The SARS-CoV-2 mutation landscape is shaped before replication starts



Document title: The SARS-CoV-2 mutation landscape is shaped before replication starts
Journal: Genetics and molecular biology
Database: PERIÓDICA
System number: 000459182
ISSN: 1415-4757
Authors: 1
2
1
Institutions: 1Universidad Nacional de Cuyo, Instituto de Histología y Embriología de Mendoza, Mendoza. Argentina
2Universidad Nacional de Cuyo, Instituto de Medicina y Biología Experimental de Cuyo, Mendoza. Argentina
Year:
Season: Ene
Volumen: 46
Number: 2
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, analítico
English abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle
Disciplines: Biología
Keyword: Genética,
Virus,
SARS-CoV-2,
Mutaciones,
Replicación viral
Keyword: Virus,
Genetics,
SARS-CoV-2,
Viral replication,
Mutations
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