| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000424673 |
| ISSN: | 1415-4757 |
| Authors: | Roll, Mariana Matos1 Miranda-Vilela, Ana Luisa1 Longo, Joao Paulo Figueiro1 Agostini-Costa, Tania da Silveira2 Grisolia, Cesar Koppe1 |
| Institutions: | 1Universidade de Brasilia, Instituto de Ciencias Biologicas, Brasilia, Distrito Federal. Brasil 2Empresa Brasileira de Pesquisa Agropecuaria, Recursos Geneticos e Biotecnologia, Brasilia, Distrito Federal. Brasil |
| Year: | 2018 |
| Season: | Dic |
| Volumen: | 41 |
| Number: | 4 |
| Pages: | 858-869 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Abstract Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associ-ated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasilienseCamb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed toinvestigatein vivothe antioxidant and anti-inflammatory effects of pequi oil on hemogram and DNA damage inhealthy young adult and older middle-aged Swiss mice of both genders. Animals, aged 6-7 and 11-12 months, wereorally treated for 15 days with pequi oil at 30 mg/day. Blood samples were used for hemogram and comet assay, andbone marrow for micronucleus test. Female controls of 11-12 months had significantly lower haemoglobin andhematocrit than those of 6-7 months. Treatment with pequi oil improved this state, removing the differences. Pequi oilhad no genotoxic or clastogenic effects and significantly increased lymphocytes and decreased neutrophils+mono-cytes in females of 11-12 months, removing the significant differences observed between controls of 6-7 and 11-12months. The results suggest that dietary supplementation with pequi oil could protect against anemia, inflammationand oxidative stress related to aging, helping to prevent aging-related chronic degenerative diseases, mainly for females |
| Disciplines: | Agrociencias, Medicina, Química |
| Keyword: | Frutales, Geriatría, Bioquímica, Inflamación, Envejecimiento, Estrés oxidativo, Ensayo del cometa, Micronúcleo, Antioxidantes, Medicina popular |
| Keyword: | Fruit trees, Geriatrics, Biochemistry, Inflammation, Aging, Oxidative stress, Comet assay, Micronucleus, Antioxidants, Folk medicine |
| Full text: | Texto completo (Ver PDF) |
