| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000459189 |
| ISSN: | 1415-4757 |
| Authors: | Diniz-Sobrinho, Francisco de A1 Moura, Jeane de O2 Bajay, Miklos M3 Branco, Leonardo Castelo4 Bezerra, Roosevelt D.S2 Araújo, Adriana M. de5 |
| Institutions: | 1Universidade Federal do Piaui, Teresina, Piaui. Brasil 2Instituto Federal do Piaui, Teresina, Piaui. Brasil 3Universidade do Estado de Santa Catarina, Laguna, Santa Catarina. Brasil 4Universidade Federal Rural da Amazonia, Belem, Para. Brasil 5Empresa Brasileira de Pesquisa Agropecuaria, Pantanal, Corumba, Mato Grosso do Sul. Brasil |
| Year: | 2023 |
| Volumen: | 46 |
| Number: | 3 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| English abstract | Identifying genome regions subject to selection in local breeds of Brazil is an opportunity to elucidate the C. hircus genome plasticity, flowing the colonization history of the country. Using SNP Bead Chip Illumina 50K genotyping of Brazilian Anglo-Nubian (standardized breed) and Marota (local endangered population from the semiarid area of Brazil) to show outliers loci in genome regions subject to selection. After applying data quality control, 45,600 SNPs were included in this investigation. Principal component analysis (PCAdapt) and FDIST2 analysis signalized 14 genomic regions more affected by selection in the Brazilian dry zone environment. The genome study signalized regions that are close to the sequences of genes related to growth and embryonic skeletal development (FGF12, AMPD2, OSTN). In addition, flagged regions close to the genes UTSB2 and SLC5A2 contribute to research on functional adaptation with low water needs and poor nutritive diet to survive. Both genes encode proteins that act on osmotic pathways and avoid cell flooding on stress cell responses. Further studies on the genetic role and involvement of these outliers’ genomic regions, building a robust conceptual high-resolution map of natural selection drives, help to achieve hardiness candidate genes linked to the evolutionary history of Capra hircus in the semiarid area of Brazil |
| Disciplines: | Biología, Medicina veterinaria y zootecnia |
| Keyword: | Ovinos y caprinos, Genética, Capra hircus, Brasil, Selección natural, Regiones genómicas |
| Keyword: | Sheep and goats, Genetics, Capra hircus, Brazil, Natural selection, Genomic regions |
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