| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000410341 |
| ISSN: | 1415-4757 |
| Authors: | Kremer, Frederico Schmitt1 McBride, Alan John Alexander1 Pinto, Luciano da Silva1 |
| Institutions: | 1Universidade Federal de Pelotas, Centro de Desenvolvimento Tecnologico, Pelotas, Rio Grande do Sul. Brasil |
| Year: | 2017 |
| Season: | Sep |
| Volumen: | 40 |
| Number: | 3 |
| Pages: | 553-576 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Revisión bibliográfica |
| Approach: | Analítico |
| English abstract | The introduction of next-generation sequencing (NGS) had a significant effect on the availability of genomic information, leading to an increase in the number of sequenced genomes from a large spectrum of organisms. Unfortunately, due to the limitations implied by the short-read sequencing platforms, most of these newly sequenced genomes remained as “drafts”, incomplete representations of the whole genetic content. The previous genome sequencing studies indicated that finishing a genome sequenced by NGS, even bacteria, may require additional sequencing to fill the gaps, making the entire process very expensive. As such, several in silico approaches have been developed to optimize the genome assemblies and facilitate the finishing process. The present review aims to explore some free (open source, in many cases) tools that are available to facilitate genome finishing |
| Disciplines: | Biología, Medicina |
| Keyword: | Genética, Biología molecular, Genómica, Secuencia génica, Nuevas tecnologías |
| Keyword: | Biology, Medicine, Genetics, Molecular biology, Genomics, Gene sequence, New technologies |
| Full text: | Texto completo (Ver HTML) |
