Glucose Abnormalities in Urban Hispanics: diagnosis, prevalence, risk predictive value, and association with metabolic syndrome and high blood pressure
Document title: Glucose Abnormalities in Urban Hispanics: diagnosis, prevalence, risk predictive value, and association with metabolic syndrome and high blood pressure
Journal: Diabetes internacional
Database: PERIÓDICA
System number: 000424031
ISSN: 1856-965X
Authors: 1
1
2
Institutions: 1Universidad Central de Venezuela, Escuela de Farmacia, Caracas, Distrito Federal. Venezuela
2Nova Southeastern University, College of Pharmacy, Fort Lauderdale, Florida. Estados Unidos de América
Year:
Volumen: 1
Number: 4
Pages: 99-106
Country: Venezuela
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract The objective is to study the prevalence of glucose abnormalities (GA), their association with metabolic syndrome (MS), and the screening value of fasting plasma glucose (FPG) and insulin in detecting impaired glucose tolerance (IGT) and diabetes mellitus (DM), were determined in an unselected sample of apparently healthy UrbanHispanics. OGGT was conducted in 592 subjects. GA were found in 34% of subjects, defined as impaired fasting glucose (IFG) (13.3%), IGT (6.9%), combined IFG+IGT (7.8%) and type2-DM (6.5%). FPG of 5.6-6.9mmol/l diagnostic of IFG missed 47.1% of subjects with IGT, and FPG >7.0mmol/l missed 53.9% of DM. GA were associated with abdominal obesity, hypertriglyceridemia, hyperinsulinemia, hypertension and MS. Prevalence of MS was greater in DM=IFG+IGT>IGT=IFG> controls. Post-load hyperinsulinemia and hyperglycemia was higher in IGT than in IFG; whereas HOMA-IR was higher in IFG. Indices of insulin secretion were markedly reduced in DM, IFG-IGT and IGT. In summary: currently recommended FPG thresholds detect only half of subjects with GA. Diagnosis of GA must include both, fasting and 2-hr postload glucose levels. Presence of fasting and post-load hyperglycemia-hyperinsulinemia in one individual may explain the increased risk in combined IFG-IGT and in DM. Because of its high prevalence, silent course, and associated increased risk, full-scale screening programs and aggressive management of GA must be implemented
Disciplines: Medicina
Keyword: Metabolismo y nutrición,
Salud pública,
Glucosa en ayuno,
Síndrome metabólico,
Intolerancia a la glucosa,
Hispanos,
Hipertensión arterial,
Prevalencia
Keyword: Metabolism and nutrition,
Public health,
Fasting glucose,
Metabolic syndrome,
Glucose intolerance,
Arterial hypertension,
Hispanics,
Prevalence
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